Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature
Abstract Background There have hardly been any reported cases of children presenting with Kaposi sarcoma as a second malignancy following treatment for acute lymphoblastic leukemia outside a transplant setting. Case presentation We report a case of a 5-year-old boy of Bantu origin, which, to our kno...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-022-03620-3 |
| _version_ | 1811328864636370944 |
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| author | Richard Nyeko Fadhil Geriga Racheal Angom Joyce Balagadde Kambugu |
| author_facet | Richard Nyeko Fadhil Geriga Racheal Angom Joyce Balagadde Kambugu |
| author_sort | Richard Nyeko |
| collection | DOAJ |
| description | Abstract Background There have hardly been any reported cases of children presenting with Kaposi sarcoma as a second malignancy following treatment for acute lymphoblastic leukemia outside a transplant setting. Case presentation We report a case of a 5-year-old boy of Bantu origin, which, to our knowledge, could be only the second reported case of oral–visceral Kaposi sarcoma after acute lymphoblastic leukemia treatment. The patient presented with a 1-month history of progressive, non-painful, soft tissue oral mass, 1 month after completing treatment for high-risk acute lymphoblastic leukemia. He was successfully treated for Kaposi sarcoma on a two-drug regimen (bleomycin and vincristine) with good clinical response. Conclusion Visceral Kaposi sarcoma as a second malignancy may occur after pediatric acute lymphoblastic leukemia treatment, but its rarity makes it unlikely to raise suspicion among clinicians, thus precluding early diagnosis and treatment. We recommend routine evaluation for Kaposi sarcoma lesions in children undergoing long-term surveillance following treatment for childhood acute leukemia. |
| first_indexed | 2024-04-13T15:33:41Z |
| format | Article |
| id | doaj.art-dedad9e2c5234cc5838455c3ff6fce5d |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-13T15:33:41Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-dedad9e2c5234cc5838455c3ff6fce5d2022-12-22T02:41:20ZengBMCJournal of Medical Case Reports1752-19472022-11-011611610.1186/s13256-022-03620-3Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literatureRichard Nyeko0Fadhil Geriga1Racheal Angom2Joyce Balagadde Kambugu3Department of Paediatric Oncology, Uganda Cancer InstituteDepartment of Paediatric Oncology, Uganda Cancer InstituteDepartment of Paediatric Oncology, Uganda Cancer InstituteDepartment of Paediatric Oncology, Uganda Cancer InstituteAbstract Background There have hardly been any reported cases of children presenting with Kaposi sarcoma as a second malignancy following treatment for acute lymphoblastic leukemia outside a transplant setting. Case presentation We report a case of a 5-year-old boy of Bantu origin, which, to our knowledge, could be only the second reported case of oral–visceral Kaposi sarcoma after acute lymphoblastic leukemia treatment. The patient presented with a 1-month history of progressive, non-painful, soft tissue oral mass, 1 month after completing treatment for high-risk acute lymphoblastic leukemia. He was successfully treated for Kaposi sarcoma on a two-drug regimen (bleomycin and vincristine) with good clinical response. Conclusion Visceral Kaposi sarcoma as a second malignancy may occur after pediatric acute lymphoblastic leukemia treatment, but its rarity makes it unlikely to raise suspicion among clinicians, thus precluding early diagnosis and treatment. We recommend routine evaluation for Kaposi sarcoma lesions in children undergoing long-term surveillance following treatment for childhood acute leukemia.https://doi.org/10.1186/s13256-022-03620-3Kaposi sarcomaAcute lymphoblastic leukemiaSecondary malignancyHHV-8Pediatric case report |
| spellingShingle | Richard Nyeko Fadhil Geriga Racheal Angom Joyce Balagadde Kambugu Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature Journal of Medical Case Reports Kaposi sarcoma Acute lymphoblastic leukemia Secondary malignancy HHV-8 Pediatric case report |
| title | Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature |
| title_full | Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature |
| title_fullStr | Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature |
| title_full_unstemmed | Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature |
| title_short | Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature |
| title_sort | oral visceral iatrogenic kaposi sarcoma following treatment for acute lymphoblastic leukemia a case report and review of the literature |
| topic | Kaposi sarcoma Acute lymphoblastic leukemia Secondary malignancy HHV-8 Pediatric case report |
| url | https://doi.org/10.1186/s13256-022-03620-3 |
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