A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10213 |
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| author | Alexander V. Aksenov Dmitrii A. Aksenov Igor A. Kurenkov Alexander V. Leontiev Nicolai A. Aksenov |
| author_facet | Alexander V. Aksenov Dmitrii A. Aksenov Igor A. Kurenkov Alexander V. Leontiev Nicolai A. Aksenov |
| author_sort | Alexander V. Aksenov |
| collection | DOAJ |
| description | The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry. |
| first_indexed | 2024-03-11T02:21:54Z |
| format | Article |
| id | doaj.art-dedaff912f2945018029f67181a0471b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:21:54Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dedaff912f2945018029f67181a0471b2023-11-18T10:50:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121021310.3390/ijms241210213A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy ButyrolactamsAlexander V. Aksenov0Dmitrii A. Aksenov1Igor A. Kurenkov2Alexander V. Leontiev3Nicolai A. Aksenov4Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, RussiaThe synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.https://www.mdpi.com/1422-0067/24/12/10213chalconescascade transformations5-hydroxy-3-pyrrolin-2-ones |
| spellingShingle | Alexander V. Aksenov Dmitrii A. Aksenov Igor A. Kurenkov Alexander V. Leontiev Nicolai A. Aksenov A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams International Journal of Molecular Sciences chalcones cascade transformations 5-hydroxy-3-pyrrolin-2-ones |
| title | A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams |
| title_full | A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams |
| title_fullStr | A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams |
| title_full_unstemmed | A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams |
| title_short | A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams |
| title_sort | new convenient way to fully substituted α β unsaturated γ hydroxy butyrolactams |
| topic | chalcones cascade transformations 5-hydroxy-3-pyrrolin-2-ones |
| url | https://www.mdpi.com/1422-0067/24/12/10213 |
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