Optimized photo-stimulation of halorhodopsin for long-term neuronal inhibition
Abstract Background Optogenetic silencing techniques have expanded the causal understanding of the functions of diverse neuronal cell types in both the healthy and diseased brain. A widely used inhibitory optogenetic actuator is eNpHR3.0, an improved version of the light-driven chloride pump halorho...
Main Authors: | Chuanqiang Zhang, Shang Yang, Tom Flossmann, Shiqiang Gao, Otto W. Witte, Georg Nagel, Knut Holthoff, Knut Kirmse |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-11-01
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Series: | BMC Biology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12915-019-0717-6 |
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