Protective Effect of <i>Panicum dichotomiflorum</i> in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) is a common disease in aging men. <i>Panicum dichotomiflorum</i> (PD) is an annual grass species of Poaceae that is distributed worldwide. The present study examined whether PD has a protective effect against BPH. BPH was generated in rats by daily subc...
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MDPI AG
2024-02-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | https://www.mdpi.com/2218-0532/92/1/13 |
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| author | Eun Bok Baek Eun-Ju Hong Jung-Hee Kim Min Kim Jongmin Ahn Hyo-Jung Kwun |
| author_facet | Eun Bok Baek Eun-Ju Hong Jung-Hee Kim Min Kim Jongmin Ahn Hyo-Jung Kwun |
| author_sort | Eun Bok Baek |
| collection | DOAJ |
| description | Benign prostatic hyperplasia (BPH) is a common disease in aging men. <i>Panicum dichotomiflorum</i> (PD) is an annual grass species of Poaceae that is distributed worldwide. The present study examined whether PD has a protective effect against BPH. BPH was generated in rats by daily subcutaneous administration of testosterone for four weeks. During this period, the rats were also given daily oral gavages of an extract of PD (150 mg/kg). After the final treatment, all animals were euthanized and their prostates were collected and weighed. In BPH model rats, the prostate weight and levels of dihydrotestosterone (DHT) and 5α-reductase expression were inhibited following treatment with PD extract. Testosterone-induced increases in prostate gland epithelial thickness and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA) were markedly suppressed in PD-treated rats, whereas cleaved caspase-3 levels were increased. PD administration also decreased the expression of transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF), the phosphorylation of Akt, and inflammatory cytokines levels. Taken together, these results show that PD extract protects against testosterone-induced BPH progression by alleviating prostate cell growth and reducing levels of growth factors and inflammatory cytokines, indicating that PD extract may have potential in protecting against BPH. |
| first_indexed | 2024-04-24T17:51:04Z |
| format | Article |
| id | doaj.art-dedfc21959c84252af55fea2be7e8f86 |
| institution | Directory Open Access Journal |
| issn | 0036-8709 2218-0532 |
| language | English |
| last_indexed | 2024-04-24T17:51:04Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-dedfc21959c84252af55fea2be7e8f862024-03-27T14:03:27ZengMDPI AGScientia Pharmaceutica0036-87092218-05322024-02-019211310.3390/scipharm92010013Protective Effect of <i>Panicum dichotomiflorum</i> in a Rodent Model of Testosterone-Induced Benign Prostatic HyperplasiaEun Bok Baek0Eun-Ju Hong1Jung-Hee Kim2Min Kim3Jongmin Ahn4Hyo-Jung Kwun5Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaNatural Product Central Bank & Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 34141, Republic of KoreaNatural Product Central Bank & Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 34141, Republic of KoreaNatural Product Central Bank & Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 34141, Republic of KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaBenign prostatic hyperplasia (BPH) is a common disease in aging men. <i>Panicum dichotomiflorum</i> (PD) is an annual grass species of Poaceae that is distributed worldwide. The present study examined whether PD has a protective effect against BPH. BPH was generated in rats by daily subcutaneous administration of testosterone for four weeks. During this period, the rats were also given daily oral gavages of an extract of PD (150 mg/kg). After the final treatment, all animals were euthanized and their prostates were collected and weighed. In BPH model rats, the prostate weight and levels of dihydrotestosterone (DHT) and 5α-reductase expression were inhibited following treatment with PD extract. Testosterone-induced increases in prostate gland epithelial thickness and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA) were markedly suppressed in PD-treated rats, whereas cleaved caspase-3 levels were increased. PD administration also decreased the expression of transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF), the phosphorylation of Akt, and inflammatory cytokines levels. Taken together, these results show that PD extract protects against testosterone-induced BPH progression by alleviating prostate cell growth and reducing levels of growth factors and inflammatory cytokines, indicating that PD extract may have potential in protecting against BPH.https://www.mdpi.com/2218-0532/92/1/13apoptosisbenign prostatic hyperplasiagrowth factorinflammation<i>Panicum dichotomiflorum</i>proliferation |
| spellingShingle | Eun Bok Baek Eun-Ju Hong Jung-Hee Kim Min Kim Jongmin Ahn Hyo-Jung Kwun Protective Effect of <i>Panicum dichotomiflorum</i> in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia Scientia Pharmaceutica apoptosis benign prostatic hyperplasia growth factor inflammation <i>Panicum dichotomiflorum</i> proliferation |
| title | Protective Effect of <i>Panicum dichotomiflorum</i> in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia |
| title_full | Protective Effect of <i>Panicum dichotomiflorum</i> in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia |
| title_fullStr | Protective Effect of <i>Panicum dichotomiflorum</i> in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia |
| title_full_unstemmed | Protective Effect of <i>Panicum dichotomiflorum</i> in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia |
| title_short | Protective Effect of <i>Panicum dichotomiflorum</i> in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia |
| title_sort | protective effect of i panicum dichotomiflorum i in a rodent model of testosterone induced benign prostatic hyperplasia |
| topic | apoptosis benign prostatic hyperplasia growth factor inflammation <i>Panicum dichotomiflorum</i> proliferation |
| url | https://www.mdpi.com/2218-0532/92/1/13 |
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