Histamine Neurons In The Tuberomamillary Nucleus: A Whole Center Or Distinct Subpopulations?
Histamine axons originate from a single source, the tuberomamillary nucleus of the posterior hypothalamus, to innervate almost all CNS regions. This feature, a compact cell group with widely distributed fibers, resembles that of other amines systems, such as noradrenaline or serotonin, and is consis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-05-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00033/full |
| _version_ | 1811315556749410304 |
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| author | Patrizio eBlandina Gustavo eProvensi Leonardo eMunari Maria Beatrice ePassani |
| author_facet | Patrizio eBlandina Gustavo eProvensi Leonardo eMunari Maria Beatrice ePassani |
| author_sort | Patrizio eBlandina |
| collection | DOAJ |
| description | Histamine axons originate from a single source, the tuberomamillary nucleus of the posterior hypothalamus, to innervate almost all CNS regions. This feature, a compact cell group with widely distributed fibers, resembles that of other amines systems, such as noradrenaline or serotonin, and is consistent with a function for histamine over a host of physiological processes, including the regulation of the sleep-wake cycle, appetite, endocrine homeostasis, body temperature, pain perception, learning, memory and emotion. An important question is whether these diverse physiological roles are served by different histamine neuronal subpopulation. While the histamine system is generally regarded as one single functional unit that provides histamine throughout the brain, evidence is beginning to accumulate in favour of heterogeneity of the histamine neurons. The aim of this review is to summarize experimental evidence demonstrating that histamine neurons are heterogeneous, organized into functionally distinct circuits, impinging on different brain regions, and displaying selective control mechanisms. This could imply independent functions of subsets of histamine neurons according to their respective origin and terminal projections. |
| first_indexed | 2024-04-13T11:32:26Z |
| format | Article |
| id | doaj.art-dee267d9617a4573ac058a5a0ef5fa6e |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-04-13T11:32:26Z |
| publishDate | 2012-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-dee267d9617a4573ac058a5a0ef5fa6e2022-12-22T02:48:32ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372012-05-01610.3389/fnsys.2012.0003323346Histamine Neurons In The Tuberomamillary Nucleus: A Whole Center Or Distinct Subpopulations?Patrizio eBlandina0Gustavo eProvensi1Leonardo eMunari2Maria Beatrice ePassani3Università di FirenzeUniversità di FirenzeUniversità di FirenzeUniversità di FirenzeHistamine axons originate from a single source, the tuberomamillary nucleus of the posterior hypothalamus, to innervate almost all CNS regions. This feature, a compact cell group with widely distributed fibers, resembles that of other amines systems, such as noradrenaline or serotonin, and is consistent with a function for histamine over a host of physiological processes, including the regulation of the sleep-wake cycle, appetite, endocrine homeostasis, body temperature, pain perception, learning, memory and emotion. An important question is whether these diverse physiological roles are served by different histamine neuronal subpopulation. While the histamine system is generally regarded as one single functional unit that provides histamine throughout the brain, evidence is beginning to accumulate in favour of heterogeneity of the histamine neurons. The aim of this review is to summarize experimental evidence demonstrating that histamine neurons are heterogeneous, organized into functionally distinct circuits, impinging on different brain regions, and displaying selective control mechanisms. This could imply independent functions of subsets of histamine neurons according to their respective origin and terminal projections.http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00033/fullHistaminec-fosGABAstressGABAA-RH3-R antagonist |
| spellingShingle | Patrizio eBlandina Gustavo eProvensi Leonardo eMunari Maria Beatrice ePassani Histamine Neurons In The Tuberomamillary Nucleus: A Whole Center Or Distinct Subpopulations? Frontiers in Systems Neuroscience Histamine c-fos GABA stress GABAA-R H3-R antagonist |
| title | Histamine Neurons In The Tuberomamillary Nucleus: A Whole Center Or Distinct Subpopulations? |
| title_full | Histamine Neurons In The Tuberomamillary Nucleus: A Whole Center Or Distinct Subpopulations? |
| title_fullStr | Histamine Neurons In The Tuberomamillary Nucleus: A Whole Center Or Distinct Subpopulations? |
| title_full_unstemmed | Histamine Neurons In The Tuberomamillary Nucleus: A Whole Center Or Distinct Subpopulations? |
| title_short | Histamine Neurons In The Tuberomamillary Nucleus: A Whole Center Or Distinct Subpopulations? |
| title_sort | histamine neurons in the tuberomamillary nucleus a whole center or distinct subpopulations |
| topic | Histamine c-fos GABA stress GABAA-R H3-R antagonist |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00033/full |
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