Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patients
Abstract Background The study aimed to investigate the correlation between type 1 diabetes (T1D) and lumbar disc degeneration (LDD). Methods A retrospective analysis of 118 patients with T1D recruited from January 2014 to March 2019 was performed, and multivariate logistic regression was used to ana...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13018-020-01784-6 |
| _version_ | 1798039083591663616 |
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| author | Rui Chen Xinjie Liang Tianji Huang Weiyang Zhong Xiaoji Luo |
| author_facet | Rui Chen Xinjie Liang Tianji Huang Weiyang Zhong Xiaoji Luo |
| author_sort | Rui Chen |
| collection | DOAJ |
| description | Abstract Background The study aimed to investigate the correlation between type 1 diabetes (T1D) and lumbar disc degeneration (LDD). Methods A retrospective analysis of 118 patients with T1D recruited from January 2014 to March 2019 was performed, and multivariate logistic regression was used to analyse the incidence of T1D; the age, sex, and body mass index (BMI) of the patients; the disease duration and the glycosylated haemoglobin and venous blood glucose levels. All patients who suffered low back pain were assessed by MRI using the Pfirrmann grading system. Results A total of 118 patients with an average age of 36.99 ± 17.01 (8–85 years) were reviewed. The mean hospitalization duration, venous glucose fluctuation range, glycated haemoglobin level, highest venous glucose level, venous glucose level, and disease course duration were 13.98 ± 10.16 days, 14.99 ± 5.87 mmol/L, 9.85 ± 2.52 mmol/L, 25.29 ± 7.92 mmol/L, 13.03 ± 5.75 mmol/L and 7.30 ± 8.41 years. The average Pfirrmann scores of the different discs were 2.20 ± 0.62 (L1–2), 2.35 ± 0.67 (L2–3), 2.90 ± 0.45 (L3–4), 4.20 ± 0.52 (L4–5) and 4.10 ± 0.72 (L5–S1). The patients with T1D showed severe disc degeneration. The male sex, glycosylated haemoglobin, venous glucose and venous glucose fluctuations were significantly associated with LDD (P < 0.05). Conclusions Glycosylated haemoglobin, the male, venous glucose and the venous glucose fluctuation range were risk factors for LDD. |
| first_indexed | 2024-04-11T21:49:01Z |
| format | Article |
| id | doaj.art-dee2e403f7cf48adb7ff8ea21b237171 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T21:49:01Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-dee2e403f7cf48adb7ff8ea21b2371712022-12-22T04:01:18ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-07-011511710.1186/s13018-020-01784-6Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patientsRui Chen0Xinjie Liang1Tianji Huang2Weiyang Zhong3Xiaoji Luo4Department of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Pain Management, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background The study aimed to investigate the correlation between type 1 diabetes (T1D) and lumbar disc degeneration (LDD). Methods A retrospective analysis of 118 patients with T1D recruited from January 2014 to March 2019 was performed, and multivariate logistic regression was used to analyse the incidence of T1D; the age, sex, and body mass index (BMI) of the patients; the disease duration and the glycosylated haemoglobin and venous blood glucose levels. All patients who suffered low back pain were assessed by MRI using the Pfirrmann grading system. Results A total of 118 patients with an average age of 36.99 ± 17.01 (8–85 years) were reviewed. The mean hospitalization duration, venous glucose fluctuation range, glycated haemoglobin level, highest venous glucose level, venous glucose level, and disease course duration were 13.98 ± 10.16 days, 14.99 ± 5.87 mmol/L, 9.85 ± 2.52 mmol/L, 25.29 ± 7.92 mmol/L, 13.03 ± 5.75 mmol/L and 7.30 ± 8.41 years. The average Pfirrmann scores of the different discs were 2.20 ± 0.62 (L1–2), 2.35 ± 0.67 (L2–3), 2.90 ± 0.45 (L3–4), 4.20 ± 0.52 (L4–5) and 4.10 ± 0.72 (L5–S1). The patients with T1D showed severe disc degeneration. The male sex, glycosylated haemoglobin, venous glucose and venous glucose fluctuations were significantly associated with LDD (P < 0.05). Conclusions Glycosylated haemoglobin, the male, venous glucose and the venous glucose fluctuation range were risk factors for LDD.http://link.springer.com/article/10.1186/s13018-020-01784-6Type 1 diabetesLumbar disc degenerationRisk factor |
| spellingShingle | Rui Chen Xinjie Liang Tianji Huang Weiyang Zhong Xiaoji Luo Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patients Journal of Orthopaedic Surgery and Research Type 1 diabetes Lumbar disc degeneration Risk factor |
| title | Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patients |
| title_full | Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patients |
| title_fullStr | Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patients |
| title_full_unstemmed | Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patients |
| title_short | Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patients |
| title_sort | effects of type 1 diabetes mellitus on lumbar disc degeneration a retrospective study of 118 patients |
| topic | Type 1 diabetes Lumbar disc degeneration Risk factor |
| url | http://link.springer.com/article/10.1186/s13018-020-01784-6 |
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