Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6
Allergy and autoimmune diseases are characterised by a multifactorial pathogenic background. Several genes involved in the control of innate and adaptive immunity have been associated with diseases and variably combine with each other as well as with environmental factors and epigenetic processes to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-07-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/7/7/70 |
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| author | Giuseppe A. Ramirez Lavinia A. Coletto Clara Sciorati Enrica P. Bozzolo Paolo Manunta Patrizia Rovere-Querini Angelo A. Manfredi |
| author_facet | Giuseppe A. Ramirez Lavinia A. Coletto Clara Sciorati Enrica P. Bozzolo Paolo Manunta Patrizia Rovere-Querini Angelo A. Manfredi |
| author_sort | Giuseppe A. Ramirez |
| collection | DOAJ |
| description | Allergy and autoimmune diseases are characterised by a multifactorial pathogenic background. Several genes involved in the control of innate and adaptive immunity have been associated with diseases and variably combine with each other as well as with environmental factors and epigenetic processes to shape the characteristics of individual manifestations. Systemic or local perturbations in salt/water balance and in ion exchanges between the intra- and extracellular spaces or among tissues play a role. In this field, usually referred to as elementary immunology, novel evidence has been recently acquired on the role of members of the transient potential receptor (TRP) channel family in several cellular mechanisms of potential significance for the pathophysiology of the immune response. TRP canonical channel 6 (TRPC6) is emerging as a functional element for the control of calcium currents in immune-committed cells and target tissues. In fact, TRPC6 influences leukocytes’ tasks such as transendothelial migration, chemotaxis, phagocytosis and cytokine release. TRPC6 also modulates the sensitivity of immune cells to apoptosis and influences tissue susceptibility to ischemia-reperfusion injury and excitotoxicity. Here, we provide a view of the interactions between ion exchanges and inflammation with a focus on the pathogenesis of immune-mediated diseases and potential future therapeutic implications. |
| first_indexed | 2024-03-12T09:53:49Z |
| format | Article |
| id | doaj.art-dee623bab0e147d597436e96a09047d5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T09:53:49Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-dee623bab0e147d597436e96a09047d52023-09-02T12:23:36ZengMDPI AGCells2073-44092018-07-01777010.3390/cells7070070cells7070070Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6Giuseppe A. Ramirez0Lavinia A. Coletto1Clara Sciorati2Enrica P. Bozzolo3Paolo Manunta4Patrizia Rovere-Querini5Angelo A. Manfredi6Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele, 20132 Milan, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele, 20132 Milan, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele, 20132 Milan, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele, 20132 Milan, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele, 20132 Milan, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele, 20132 Milan, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele, 20132 Milan, ItalyAllergy and autoimmune diseases are characterised by a multifactorial pathogenic background. Several genes involved in the control of innate and adaptive immunity have been associated with diseases and variably combine with each other as well as with environmental factors and epigenetic processes to shape the characteristics of individual manifestations. Systemic or local perturbations in salt/water balance and in ion exchanges between the intra- and extracellular spaces or among tissues play a role. In this field, usually referred to as elementary immunology, novel evidence has been recently acquired on the role of members of the transient potential receptor (TRP) channel family in several cellular mechanisms of potential significance for the pathophysiology of the immune response. TRP canonical channel 6 (TRPC6) is emerging as a functional element for the control of calcium currents in immune-committed cells and target tissues. In fact, TRPC6 influences leukocytes’ tasks such as transendothelial migration, chemotaxis, phagocytosis and cytokine release. TRPC6 also modulates the sensitivity of immune cells to apoptosis and influences tissue susceptibility to ischemia-reperfusion injury and excitotoxicity. Here, we provide a view of the interactions between ion exchanges and inflammation with a focus on the pathogenesis of immune-mediated diseases and potential future therapeutic implications.http://www.mdpi.com/2073-4409/7/7/70TRPC6elementary immunologyinflammationcalciumsodiumneutrophilslymphocytesendotheliumplatelets |
| spellingShingle | Giuseppe A. Ramirez Lavinia A. Coletto Clara Sciorati Enrica P. Bozzolo Paolo Manunta Patrizia Rovere-Querini Angelo A. Manfredi Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6 Cells TRPC6 elementary immunology inflammation calcium sodium neutrophils lymphocytes endothelium platelets |
| title | Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6 |
| title_full | Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6 |
| title_fullStr | Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6 |
| title_full_unstemmed | Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6 |
| title_short | Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6 |
| title_sort | ion channels and transporters in inflammation special focus on trp channels and trpc6 |
| topic | TRPC6 elementary immunology inflammation calcium sodium neutrophils lymphocytes endothelium platelets |
| url | http://www.mdpi.com/2073-4409/7/7/70 |
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