Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment
Acute myeloid leukemia (AML) is a hematological malignancy originating from defective hematopoietic stem cells in the bone marrow. In spite of the recent approval of several molecular targeted therapies for AML treatment, disease recurrence remains an issue. Interestingly, increasing evidence has po...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Non-Coding RNA |
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| Online Access: | https://www.mdpi.com/2311-553X/8/4/50 |
| _version_ | 1797431858516983808 |
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| author | Francesca Liccardo Alessia Iaiza Martyna Śniegocka Silvia Masciarelli Francesco Fazi |
| author_facet | Francesca Liccardo Alessia Iaiza Martyna Śniegocka Silvia Masciarelli Francesco Fazi |
| author_sort | Francesca Liccardo |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) is a hematological malignancy originating from defective hematopoietic stem cells in the bone marrow. In spite of the recent approval of several molecular targeted therapies for AML treatment, disease recurrence remains an issue. Interestingly, increasing evidence has pointed out the relevance of bone marrow (BM) niche remodeling during leukemia onset and progression. Complex crosstalk between AML cells and microenvironment components shapes the leukemic BM niche, consequently affecting therapy responsiveness. Notably, circular RNAs are a new class of RNAs found to be relevant in AML progression and chemoresistance. In this review, we provided an overview of AML-driven niche remodeling. In particular, we analyzed the role of circRNAs and their possible contribution to cell–cell communication within the leukemic BM microenvironment. Understanding these mechanisms will help develop a more effective treatment for AML. |
| first_indexed | 2024-03-09T09:51:21Z |
| format | Article |
| id | doaj.art-dee8fab911e747d384c60b8164459975 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-09T09:51:21Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-dee8fab911e747d384c60b81644599752023-12-02T00:06:42ZengMDPI AGNon-Coding RNA2311-553X2022-07-01845010.3390/ncrna8040050Circular RNAs Activity in the Leukemic Bone Marrow MicroenvironmentFrancesca Liccardo0Alessia Iaiza1Martyna Śniegocka2Silvia Masciarelli3Francesco Fazi4Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14-16, 00161 Rome, ItalyDepartment of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14-16, 00161 Rome, ItalyDepartment of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14-16, 00161 Rome, ItalyDepartment of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14-16, 00161 Rome, ItalyDepartment of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14-16, 00161 Rome, ItalyAcute myeloid leukemia (AML) is a hematological malignancy originating from defective hematopoietic stem cells in the bone marrow. In spite of the recent approval of several molecular targeted therapies for AML treatment, disease recurrence remains an issue. Interestingly, increasing evidence has pointed out the relevance of bone marrow (BM) niche remodeling during leukemia onset and progression. Complex crosstalk between AML cells and microenvironment components shapes the leukemic BM niche, consequently affecting therapy responsiveness. Notably, circular RNAs are a new class of RNAs found to be relevant in AML progression and chemoresistance. In this review, we provided an overview of AML-driven niche remodeling. In particular, we analyzed the role of circRNAs and their possible contribution to cell–cell communication within the leukemic BM microenvironment. Understanding these mechanisms will help develop a more effective treatment for AML.https://www.mdpi.com/2311-553X/8/4/50circRNAacute myeloid leukemiabone marrow nichetumor microenvironmentnon-coding RNAhematopoietic stem cell |
| spellingShingle | Francesca Liccardo Alessia Iaiza Martyna Śniegocka Silvia Masciarelli Francesco Fazi Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment Non-Coding RNA circRNA acute myeloid leukemia bone marrow niche tumor microenvironment non-coding RNA hematopoietic stem cell |
| title | Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment |
| title_full | Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment |
| title_fullStr | Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment |
| title_full_unstemmed | Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment |
| title_short | Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment |
| title_sort | circular rnas activity in the leukemic bone marrow microenvironment |
| topic | circRNA acute myeloid leukemia bone marrow niche tumor microenvironment non-coding RNA hematopoietic stem cell |
| url | https://www.mdpi.com/2311-553X/8/4/50 |
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