Altered brain responses to specific negative emotions in schizophrenia
Deficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases are poorly understood. Previous research, mainly focused on emotional face processing and emotion recognition deficits, has shown controverted results. Furthermore, the use of faces has been questione...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221003387 |
| _version_ | 1818353436680257536 |
|---|---|
| author | Maria Angeles Garcia-Leon Paola Fuentes-Claramonte Alicia Valiente-Gómez Carmen Natividad Pilar Salgado-Pineda Jesús J. Gomar Amalia Guerrero-Pedraza Francisco Portillo Jordi Ortiz-Gil Silvia Alonso-Lana Teresa Maristany Joaquim Raduà Raymond Salvador Salvador Sarró Edith Pomarol-Clotet |
| author_facet | Maria Angeles Garcia-Leon Paola Fuentes-Claramonte Alicia Valiente-Gómez Carmen Natividad Pilar Salgado-Pineda Jesús J. Gomar Amalia Guerrero-Pedraza Francisco Portillo Jordi Ortiz-Gil Silvia Alonso-Lana Teresa Maristany Joaquim Raduà Raymond Salvador Salvador Sarró Edith Pomarol-Clotet |
| author_sort | Maria Angeles Garcia-Leon |
| collection | DOAJ |
| description | Deficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases are poorly understood. Previous research, mainly focused on emotional face processing and emotion recognition deficits, has shown controverted results. Furthermore, the use of faces has been questioned for not entailing an appropriate stimulus to study emotional processing. This highlights the importance of investigating emotional processing abnormalities using evocative stimuli. For the first time, we have studied the brain responses to scenic stimuli in patients with schizophrenia. We selected scenes from the IAPS that elicit fear, disgust, happiness, and sadness. Twenty-six patients with schizophrenia and thirty age-, sex- and premorbid IQ-matched healthy controls were included. Behavioral task results show that patients tended to misclassify disgust and sadness as fear. Brain responses in patients were different from controls in images eliciting disgust and fear. In response to disgust images, patients hyperactivated the right temporal cortex, which was not activated by the controls. With fear images, hyperactivation was observed in brain regions involved in fear processing, including midline regions from the medial frontal cortex to the anterior cingulate cortex, the superior frontal gyrus, inferior and superior temporal cortex, and visual areas. These results suggest that schizophrenia is characterized by hyper-responsivity to stimuli evoking high-arousal, negative emotions, and a bias towards fear in emotion recognition. |
| first_indexed | 2024-12-13T19:09:30Z |
| format | Article |
| id | doaj.art-dee99548348946b7b15b4485e226cc72 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-13T19:09:30Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-dee99548348946b7b15b4485e226cc722022-12-21T23:34:27ZengElsevierNeuroImage: Clinical2213-15822021-01-0132102894Altered brain responses to specific negative emotions in schizophreniaMaria Angeles Garcia-Leon0Paola Fuentes-Claramonte1Alicia Valiente-Gómez2Carmen Natividad3Pilar Salgado-Pineda4Jesús J. Gomar5Amalia Guerrero-Pedraza6Francisco Portillo7Jordi Ortiz-Gil8Silvia Alonso-Lana9Teresa Maristany10Joaquim Raduà11Raymond Salvador12Salvador Sarró13Edith Pomarol-Clotet14FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), SpainIMIM (Hospital del Mar Medical Research Institute), Barcelona, SpainHospital Mare de Déu de la Mercè, Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), SpainLitwin-Zucker Alzheimer’s Disease Center, Feinstein Institute, Manhassett, NY, USABenito Menni Complex Assistencial en Salut Mental, Barcelona, SpainBenito Menni Complex Assistencial en Salut Mental, Barcelona, SpainGeneral Hospital of Granollers, Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC), Barcelona, SpainHospital Sant Joan de Déu, Esplugues de Llobregat, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Imaging of Mood- and Anxiety-Related Disorders(IMARD) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Early Psychosis: Interventions and Clinical-Detection (EPIC) Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King College London, London, UK; Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Corresponding author at: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.Deficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases are poorly understood. Previous research, mainly focused on emotional face processing and emotion recognition deficits, has shown controverted results. Furthermore, the use of faces has been questioned for not entailing an appropriate stimulus to study emotional processing. This highlights the importance of investigating emotional processing abnormalities using evocative stimuli. For the first time, we have studied the brain responses to scenic stimuli in patients with schizophrenia. We selected scenes from the IAPS that elicit fear, disgust, happiness, and sadness. Twenty-six patients with schizophrenia and thirty age-, sex- and premorbid IQ-matched healthy controls were included. Behavioral task results show that patients tended to misclassify disgust and sadness as fear. Brain responses in patients were different from controls in images eliciting disgust and fear. In response to disgust images, patients hyperactivated the right temporal cortex, which was not activated by the controls. With fear images, hyperactivation was observed in brain regions involved in fear processing, including midline regions from the medial frontal cortex to the anterior cingulate cortex, the superior frontal gyrus, inferior and superior temporal cortex, and visual areas. These results suggest that schizophrenia is characterized by hyper-responsivity to stimuli evoking high-arousal, negative emotions, and a bias towards fear in emotion recognition.http://www.sciencedirect.com/science/article/pii/S2213158221003387SchizophreniaIAPSScenic stimulifMRIEmotions |
| spellingShingle | Maria Angeles Garcia-Leon Paola Fuentes-Claramonte Alicia Valiente-Gómez Carmen Natividad Pilar Salgado-Pineda Jesús J. Gomar Amalia Guerrero-Pedraza Francisco Portillo Jordi Ortiz-Gil Silvia Alonso-Lana Teresa Maristany Joaquim Raduà Raymond Salvador Salvador Sarró Edith Pomarol-Clotet Altered brain responses to specific negative emotions in schizophrenia NeuroImage: Clinical Schizophrenia IAPS Scenic stimuli fMRI Emotions |
| title | Altered brain responses to specific negative emotions in schizophrenia |
| title_full | Altered brain responses to specific negative emotions in schizophrenia |
| title_fullStr | Altered brain responses to specific negative emotions in schizophrenia |
| title_full_unstemmed | Altered brain responses to specific negative emotions in schizophrenia |
| title_short | Altered brain responses to specific negative emotions in schizophrenia |
| title_sort | altered brain responses to specific negative emotions in schizophrenia |
| topic | Schizophrenia IAPS Scenic stimuli fMRI Emotions |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221003387 |
| work_keys_str_mv | AT mariaangelesgarcialeon alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT paolafuentesclaramonte alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT aliciavalientegomez alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT carmennatividad alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT pilarsalgadopineda alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT jesusjgomar alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT amaliaguerreropedraza alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT franciscoportillo alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT jordiortizgil alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT silviaalonsolana alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT teresamaristany alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT joaquimradua alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT raymondsalvador alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT salvadorsarro alteredbrainresponsestospecificnegativeemotionsinschizophrenia AT edithpomarolclotet alteredbrainresponsestospecificnegativeemotionsinschizophrenia |