The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions
Lobaria pindarensis Räsänen is an edible and medicinal lichen found in the Himalayas that has been used as ethnomedicine for years to combat inflammation. The study aimed to evaluate the ability of L. pindarensis extracts and its main depsidones to suppress inflammation and Aβ fibril formation in cu...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623002074 |
| _version_ | 1797749205413920768 |
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| author | Mei-Xia Yang Edwin Hok-Chi Cheng Dusadee Ospondpant Ka-Ki Tung Li-Song Wang Sheng-Ying Lin Queenie Wing-Sze Lai Qi-Yun Wu Ying-Jie Xia Ka-Wing Leung Ran Duan Tina Ting-Xia Dong Karl Wah-Keung Tsim |
| author_facet | Mei-Xia Yang Edwin Hok-Chi Cheng Dusadee Ospondpant Ka-Ki Tung Li-Song Wang Sheng-Ying Lin Queenie Wing-Sze Lai Qi-Yun Wu Ying-Jie Xia Ka-Wing Leung Ran Duan Tina Ting-Xia Dong Karl Wah-Keung Tsim |
| author_sort | Mei-Xia Yang |
| collection | DOAJ |
| description | Lobaria pindarensis Räsänen is an edible and medicinal lichen found in the Himalayas that has been used as ethnomedicine for years to combat inflammation. The study aimed to evaluate the ability of L. pindarensis extracts and its main depsidones to suppress inflammation and Aβ fibril formation in cultured cells induced by LPS or Aβ42. The mRNA and protein expressions of inflammatory cytokines were declined significantly by the applied herbal extracts and depsidones in the LPS/Aβ-treated immune cells (p < 0.05 to p < 0.001). In addition, the extracts and depsidones of L. pindarensis showed enhancement of phagocytotic function of microglia and disassembling aggregated Aβ fibrils in dose-dependent manners (p < 0.05 to p < 0.001). The study presents the first evidence that L. pindarensis extracts have the potential to suppress inflammation and Aβ fibril protein aggregation, making it a promising candidate for developing health food supplements for Alzheimer's patients. |
| first_indexed | 2024-03-12T16:15:54Z |
| format | Article |
| id | doaj.art-deeba67486b4412294fe741b705d23f6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T16:15:54Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-deeba67486b4412294fe741b705d23f62023-08-09T04:32:20ZengElsevierJournal of Functional Foods1756-46462023-08-01107105607The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functionsMei-Xia Yang0Edwin Hok-Chi Cheng1Dusadee Ospondpant2Ka-Ki Tung3Li-Song Wang4Sheng-Ying Lin5Queenie Wing-Sze Lai6Qi-Yun Wu7Ying-Jie Xia8Ka-Wing Leung9Ran Duan10Tina Ting-Xia Dong11Karl Wah-Keung Tsim12Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDepartment of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, ChinaKey Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, China; Corresponding author at: Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.Lobaria pindarensis Räsänen is an edible and medicinal lichen found in the Himalayas that has been used as ethnomedicine for years to combat inflammation. The study aimed to evaluate the ability of L. pindarensis extracts and its main depsidones to suppress inflammation and Aβ fibril formation in cultured cells induced by LPS or Aβ42. The mRNA and protein expressions of inflammatory cytokines were declined significantly by the applied herbal extracts and depsidones in the LPS/Aβ-treated immune cells (p < 0.05 to p < 0.001). In addition, the extracts and depsidones of L. pindarensis showed enhancement of phagocytotic function of microglia and disassembling aggregated Aβ fibrils in dose-dependent manners (p < 0.05 to p < 0.001). The study presents the first evidence that L. pindarensis extracts have the potential to suppress inflammation and Aβ fibril protein aggregation, making it a promising candidate for developing health food supplements for Alzheimer's patients.http://www.sciencedirect.com/science/article/pii/S1756464623002074Alzheimer’s diseaseInflammationFibrillar AβLichenLobaria pindarensisDepsidone |
| spellingShingle | Mei-Xia Yang Edwin Hok-Chi Cheng Dusadee Ospondpant Ka-Ki Tung Li-Song Wang Sheng-Ying Lin Queenie Wing-Sze Lai Qi-Yun Wu Ying-Jie Xia Ka-Wing Leung Ran Duan Tina Ting-Xia Dong Karl Wah-Keung Tsim The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions Journal of Functional Foods Alzheimer’s disease Inflammation Fibrillar Aβ Lichen Lobaria pindarensis Depsidone |
| title | The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions |
| title_full | The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions |
| title_fullStr | The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions |
| title_full_unstemmed | The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions |
| title_short | The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions |
| title_sort | extracts of lobaria pindarensis an edible lichen from himalayas suppress inflammatory response and fibrillation of amyloid β protein in cultured microglial cells active depsidones norstictic acid and stictic acid are responsible for the functions |
| topic | Alzheimer’s disease Inflammation Fibrillar Aβ Lichen Lobaria pindarensis Depsidone |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623002074 |
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