EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION
Aim. To evaluate effects of angiotensin converting enzyme inhibitor spirapril on efficacy of preventive antiarrhythmic therapy in patients with paroxysmal atrial fibrillation (AF).Material and methods. 40 patients with paroxysmal AF were involved in open-label, cross-over study with periods of antia...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-12-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/545 |
| _version_ | 1826949861156585472 |
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| author | L. N. Chikhireva V. I. Malahov E. S. Bykova S. F. Sokolov |
| author_facet | L. N. Chikhireva V. I. Malahov E. S. Bykova S. F. Sokolov |
| author_sort | L. N. Chikhireva |
| collection | DOAJ |
| description | Aim. To evaluate effects of angiotensin converting enzyme inhibitor spirapril on efficacy of preventive antiarrhythmic therapy in patients with paroxysmal atrial fibrillation (AF).Material and methods. 40 patients with paroxysmal AF were involved in open-label, cross-over study with periods of antiarrhythmic drug withdrawal. During 3 months all patients received by turns two types of therapy: combination of preventive antiarrhythmic therapy with spirapril 6 mg once daily - (CT group) or preventive antiarrhythmic therapy only (AT group).Results. AF-free intervals to the first and the second AF paroxysms during antiarrhythmic drug withdrawal were comparable ) in AT and CT groups (p=0,4 and p=0,6, respectively, logrank test).Conclusion. Spirapril added to the basic preventive antiarrhythmic therapy during 3 months had no effect on the length of interictal period in paroxysmal AF. |
| first_indexed | 2024-03-08T14:05:25Z |
| format | Article |
| id | doaj.art-deebb0d7fa6e47ce984d83d3fe60d6eb |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2025-02-17T22:21:28Z |
| publishDate | 2015-12-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-deebb0d7fa6e47ce984d83d3fe60d6eb2024-12-04T11:48:04ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-12-0135455310.20996/1819-6446-2007-3-5-40-43545EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATIONL. N. Chikhireva0V. I. Malahov1E. S. Bykova2S. F. Sokolov3Russian Cardiological Research Complex of Rosmedtechnology, Institute of Clinical Cardiology named after A.L. Myasnikov, MoscowRussian Cardiological Research Complex of Rosmedtechnology, Institute of Clinical Cardiology named after A.L. Myasnikov, MoscowRussian Cardiological Research Complex of Rosmedtechnology, Institute of Clinical Cardiology named after A.L. Myasnikov, MoscowRussian Cardiological Research Complex of Rosmedtechnology, Institute of Clinical Cardiology named after A.L. Myasnikov, MoscowAim. To evaluate effects of angiotensin converting enzyme inhibitor spirapril on efficacy of preventive antiarrhythmic therapy in patients with paroxysmal atrial fibrillation (AF).Material and methods. 40 patients with paroxysmal AF were involved in open-label, cross-over study with periods of antiarrhythmic drug withdrawal. During 3 months all patients received by turns two types of therapy: combination of preventive antiarrhythmic therapy with spirapril 6 mg once daily - (CT group) or preventive antiarrhythmic therapy only (AT group).Results. AF-free intervals to the first and the second AF paroxysms during antiarrhythmic drug withdrawal were comparable ) in AT and CT groups (p=0,4 and p=0,6, respectively, logrank test).Conclusion. Spirapril added to the basic preventive antiarrhythmic therapy during 3 months had no effect on the length of interictal period in paroxysmal AF.https://www.rpcardio.online/jour/article/view/545paroxysmal atrial fibrillationangiotensin-converting enzyme inhibitorsspiraprilantiarrhythmic therapy |
| spellingShingle | L. N. Chikhireva V. I. Malahov E. S. Bykova S. F. Sokolov EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION Рациональная фармакотерапия в кардиологии paroxysmal atrial fibrillation angiotensin-converting enzyme inhibitors spirapril antiarrhythmic therapy |
| title | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_full | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_fullStr | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_full_unstemmed | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_short | EFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATION |
| title_sort | effect of spirapril on the length of interictal interval in paroxysmal atrial fibrillation |
| topic | paroxysmal atrial fibrillation angiotensin-converting enzyme inhibitors spirapril antiarrhythmic therapy |
| url | https://www.rpcardio.online/jour/article/view/545 |
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