iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells

iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells

Summary: To address the limitation associated with degron based systems, we have developed iTAG, a synthetic tag based on IMiDs/CELMoDs mechanism of action that improves and addresses the limitations of both PROTAC and previous IMiDs/CeLMoDs based tags. Using structural and sequence analysis, we sys...

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Bibliographic Details
Main Authors: Habib Bouguenina, Stephanos Nicolaou, Yann-Vaï Le Bihan, Elizabeth A. Bowling, Cheyenne Calderon, John J. Caldwell, Brinley Harrington, Angela Hayes, P. Craig McAndrew, Costas Mitsopoulos, Fernando Jr. Sialana, Andrea Scarpino, Mark Stubbs, Arjun Thapaliya, Siddhartha Tyagi, Hannah Z. Wang, Francesca Wood, Rosemary Burke, Florence Raynaud, Jyoti Choudhary, Rob L.M. van Montfort, Amine Sadok, Thomas F. Westbrook, Ian Collins, Rajesh Chopra
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Oncology
Biological sciences
Biochemistry
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223011367

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