Tryptophan was metabolized into beneficial metabolites against coronary heart disease or prevented from producing harmful metabolites by the in vitro drug screening model based on Clostridium sporogenes

Tryptophan was metabolized into beneficial metabolites against coronary heart disease or prevented from producing harmful metabolites by the in vitro drug screening model based on Clostridium sporogenes

In our previous study of 2,130 Chinese patients with coronary heart disease (CHD), we found that tryptophan (TRP) metabolites contributed to elevated risks of death. Many TRP-derived metabolites require the participation of intestinal bacteria to produce, and they play an important role in the patho...

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Bibliographic Details
Main Authors: XiaoXue Tian, Yuanyuan Wu, Cheng Duan, Xiaohong Zhou, Yong Li, Jiabin Zheng, Weihua Lai, Shuyao Zhang, Lixiang Cao, Shilong Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Microbiology
Subjects:
in vitro drug screening model
tryptophan-derived metabolites
Clostridium sporogenes
indole-3-butyric acid
coronary heart disease
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1013973/full

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