Emerging roles of epigenetics in lead-induced neurotoxicity
Lead is a common environmental heavy metal contaminant. Humans are highly susceptible to lead accumulation in the body, which causes nervous system damage and leads to a variety of nervous system diseases, such as Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. Rece...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412023005263 |
| _version_ | 1797616027001946112 |
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| author | Zongqin Mei Guofen Liu Bo Zhao Zuoshun He Shiyan Gu |
| author_facet | Zongqin Mei Guofen Liu Bo Zhao Zuoshun He Shiyan Gu |
| author_sort | Zongqin Mei |
| collection | DOAJ |
| description | Lead is a common environmental heavy metal contaminant. Humans are highly susceptible to lead accumulation in the body, which causes nervous system damage and leads to a variety of nervous system diseases, such as Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. Recent research has focused on the mechanisms of lead-induced neurotoxicity at multiple levels, including DNA methylation, histone modifications, and non-coding RNAs, which are involved in various lead-induced nervous system diseases. We reviewed the latest articles and summarised the emerging roles of DNA methylation, histone modification, and non-coding RNAs in lead-induced neurotoxicity. Our summary provides a theoretical basis and directions for future research on the prevention, diagnosis, and treatment of lead-induced neurological diseases. |
| first_indexed | 2024-03-11T07:35:20Z |
| format | Article |
| id | doaj.art-deee3610e2174e05b341da324d6e65a1 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-03-11T07:35:20Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-deee3610e2174e05b341da324d6e65a12023-11-17T05:24:45ZengElsevierEnvironment International0160-41202023-11-01181108253Emerging roles of epigenetics in lead-induced neurotoxicityZongqin Mei0Guofen Liu1Bo Zhao2Zuoshun He3Shiyan Gu4Institute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, Yunnan 671000, People's Republic of ChinaInstitute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, Yunnan 671000, People's Republic of ChinaInstitute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, Yunnan 671000, People's Republic of ChinaCorresponding authors.; Institute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, Yunnan 671000, People's Republic of ChinaCorresponding authors.; Institute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, Yunnan 671000, People's Republic of ChinaLead is a common environmental heavy metal contaminant. Humans are highly susceptible to lead accumulation in the body, which causes nervous system damage and leads to a variety of nervous system diseases, such as Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. Recent research has focused on the mechanisms of lead-induced neurotoxicity at multiple levels, including DNA methylation, histone modifications, and non-coding RNAs, which are involved in various lead-induced nervous system diseases. We reviewed the latest articles and summarised the emerging roles of DNA methylation, histone modification, and non-coding RNAs in lead-induced neurotoxicity. Our summary provides a theoretical basis and directions for future research on the prevention, diagnosis, and treatment of lead-induced neurological diseases.http://www.sciencedirect.com/science/article/pii/S0160412023005263Lead exposureEpigeneticsNeurotoxicityDNA methylationHistone modificationNon-coding RNAs |
| spellingShingle | Zongqin Mei Guofen Liu Bo Zhao Zuoshun He Shiyan Gu Emerging roles of epigenetics in lead-induced neurotoxicity Environment International Lead exposure Epigenetics Neurotoxicity DNA methylation Histone modification Non-coding RNAs |
| title | Emerging roles of epigenetics in lead-induced neurotoxicity |
| title_full | Emerging roles of epigenetics in lead-induced neurotoxicity |
| title_fullStr | Emerging roles of epigenetics in lead-induced neurotoxicity |
| title_full_unstemmed | Emerging roles of epigenetics in lead-induced neurotoxicity |
| title_short | Emerging roles of epigenetics in lead-induced neurotoxicity |
| title_sort | emerging roles of epigenetics in lead induced neurotoxicity |
| topic | Lead exposure Epigenetics Neurotoxicity DNA methylation Histone modification Non-coding RNAs |
| url | http://www.sciencedirect.com/science/article/pii/S0160412023005263 |
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