Immunoglobulin G4-related thyroiditis associated with Graves’ disease: A case report
We report a case of immunoglobulin (ig)-g4-related thyroiditis associated with graves’ disease. a 45-year-old man was diagnosed with graves’ disease due to asymptomatic enlarged thyroid gland and high serum levels of thyrotropin receptor antibodies and thyroid hormones. surgical resection of the thy...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024018747 |
| _version_ | 1797267770957627392 |
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| author | Hiroyuki Takahashi Sabine Kajita Hiroshi Katoh Toshihide Matsumoto Akemi Inoue Takafumi Sangai Makoto Saegusa |
| author_facet | Hiroyuki Takahashi Sabine Kajita Hiroshi Katoh Toshihide Matsumoto Akemi Inoue Takafumi Sangai Makoto Saegusa |
| author_sort | Hiroyuki Takahashi |
| collection | DOAJ |
| description | We report a case of immunoglobulin (ig)-g4-related thyroiditis associated with graves’ disease. a 45-year-old man was diagnosed with graves’ disease due to asymptomatic enlarged thyroid gland and high serum levels of thyrotropin receptor antibodies and thyroid hormones. surgical resection of the thyroid gland was performed because of further thyroid gland enlargement and severe fluctuations in the thyroid hormonal levels, despite medical therapy with a combination of an antithyroid drug and a thyroid hormone preparation. macroscopic examination of the resected thyroid gland revealed a grayish-white diffuse swelling, and histopathological findings revealed follicular destruction, chronic inflammatory cell infiltration with diffuse igg4-positive plasma cells (IgG4/IgG >40%), storiform fibrosis, and phlebitis obliterans throughout the thyroid tissue. Additionally, there were small foci of high columnar follicular components with scalloping, resembling Graves' disease. We propose that all patients with Graves’ disease should be evaluated for coexisting IgG4-related thyroiditis to detect ophthalmopathies as soon as possible. |
| first_indexed | 2024-03-08T02:01:16Z |
| format | Article |
| id | doaj.art-deefc1f055a747da91625193bf2f33fd |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-25T01:21:52Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-deefc1f055a747da91625193bf2f33fd2024-03-09T09:26:20ZengElsevierHeliyon2405-84402024-02-01104e25843Immunoglobulin G4-related thyroiditis associated with Graves’ disease: A case reportHiroyuki Takahashi0Sabine Kajita1Hiroshi Katoh2Toshihide Matsumoto3Akemi Inoue4Takafumi Sangai5Makoto Saegusa6Department of Pathology, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan; Corresponding author. Department of Pathology, School of Medicine, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.Department of Pathology, School of Medicine, Kitasato University, Kanagawa, JapanDepartment of Breast and Endocrine Surgery, School of Medicine, Kitasato University, Kanagawa, JapanDepartment of Pathology, School of Allied Health Sciences, Kitasato University, Kanagawa, JapanDepartment of Pathology, School of Allied Health Sciences, Kitasato University, Kanagawa, JapanDepartment of Breast and Endocrine Surgery, School of Medicine, Kitasato University, Kanagawa, JapanDepartment of Pathology, School of Medicine, Kitasato University, Kanagawa, JapanWe report a case of immunoglobulin (ig)-g4-related thyroiditis associated with graves’ disease. a 45-year-old man was diagnosed with graves’ disease due to asymptomatic enlarged thyroid gland and high serum levels of thyrotropin receptor antibodies and thyroid hormones. surgical resection of the thyroid gland was performed because of further thyroid gland enlargement and severe fluctuations in the thyroid hormonal levels, despite medical therapy with a combination of an antithyroid drug and a thyroid hormone preparation. macroscopic examination of the resected thyroid gland revealed a grayish-white diffuse swelling, and histopathological findings revealed follicular destruction, chronic inflammatory cell infiltration with diffuse igg4-positive plasma cells (IgG4/IgG >40%), storiform fibrosis, and phlebitis obliterans throughout the thyroid tissue. Additionally, there were small foci of high columnar follicular components with scalloping, resembling Graves' disease. We propose that all patients with Graves’ disease should be evaluated for coexisting IgG4-related thyroiditis to detect ophthalmopathies as soon as possible.http://www.sciencedirect.com/science/article/pii/S2405844024018747IgG4Graves' disease |
| spellingShingle | Hiroyuki Takahashi Sabine Kajita Hiroshi Katoh Toshihide Matsumoto Akemi Inoue Takafumi Sangai Makoto Saegusa Immunoglobulin G4-related thyroiditis associated with Graves’ disease: A case report Heliyon IgG4 Graves' disease |
| title | Immunoglobulin G4-related thyroiditis associated with Graves’ disease: A case report |
| title_full | Immunoglobulin G4-related thyroiditis associated with Graves’ disease: A case report |
| title_fullStr | Immunoglobulin G4-related thyroiditis associated with Graves’ disease: A case report |
| title_full_unstemmed | Immunoglobulin G4-related thyroiditis associated with Graves’ disease: A case report |
| title_short | Immunoglobulin G4-related thyroiditis associated with Graves’ disease: A case report |
| title_sort | immunoglobulin g4 related thyroiditis associated with graves disease a case report |
| topic | IgG4 Graves' disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024018747 |
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