Computational Design of a Novel Dithranol–Salicylic Acid Antipsoriatic Prodrug for Esterase-Activated Topical Drug Delivery

Computational Design of a Novel Dithranol–Salicylic Acid Antipsoriatic Prodrug for Esterase-Activated Topical Drug Delivery

Psoriasis is a chronic autoimmune skin disorder characterized by the rapid overproduction of skin cells, resulting in the formation of red, inflamed, and scaly patches or plaques on the skin. Dithranol, also known as anthralin, is a very effective topical medication used in the treatment of psoriasi...

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Bibliographic Details
Main Authors: Natália Andrýsková, Jozef Motyčka, Melánia Babincová, Peter Babinec, Mária Šimaljaková
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Applied Sciences
Subjects:
psoriasis
dithranol
salicylic acid
ester bond
prodrug
quantum chemistry
Online Access:https://www.mdpi.com/2076-3417/14/3/1094

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