Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of <i>N</i>,<i>N</i>′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles
Well-defined linear and multi-arm star polymer structures were used as the templates for in situ synthesis and stabilization of silver nanoparticles (AgNPs). This approach led to hybrid nanomaterials with high stability and antibacterial activity to both Gram-positive and Gram-negative bacterial str...
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| Format: | Article |
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2020-07-01
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| Online Access: | https://www.mdpi.com/1996-1944/13/13/3037 |
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| author | Paulina Teper Anna Sotirova Violeta Mitova Natalia Oleszko-Torbus Alicja Utrata-Wesołek Neli Koseva Agnieszka Kowalczuk Barbara Mendrek |
| author_facet | Paulina Teper Anna Sotirova Violeta Mitova Natalia Oleszko-Torbus Alicja Utrata-Wesołek Neli Koseva Agnieszka Kowalczuk Barbara Mendrek |
| author_sort | Paulina Teper |
| collection | DOAJ |
| description | Well-defined linear and multi-arm star polymer structures were used as the templates for in situ synthesis and stabilization of silver nanoparticles (AgNPs). This approach led to hybrid nanomaterials with high stability and antibacterial activity to both Gram-positive and Gram-negative bacterial strains. The ecologically friendly so called “green” synthesis of nanomaterials was performed through AgNPs preparation in the aqueous solutions of star and linear poly(<i>N</i>,<i>N</i>′-dimethylaminoethyl methacrylate)s (PDMAEMAs); the process was followed with time. The size, shape, and zeta potential of the obtained hybrids were determined. To our knowledge, this is the first time that the antibacterial activity of PDMAEMA hybrid nanomaterial against <i>Bacillus subtilis</i>, <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> was investigated and assessed by minimum inhibitory concentration (MIC) and minimum biocidal concentration (MBC). Completely quaternized with ethyl bromide, star and linear PDMAEMAs were used in comparative biological tests. The modification of the polymers with in situ-formed AgNPs increased the antibacterial properties against all studied strains of bacteria by several times in comparison to non-modified polymers and quaternized polymers. These results yield novel nanohybrid materials that can be useful for applications in medicine and biology. |
| first_indexed | 2024-03-10T18:37:57Z |
| format | Article |
| id | doaj.art-def002d85fc042f9bf1d30e4b8e11fd3 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T18:37:57Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-def002d85fc042f9bf1d30e4b8e11fd32023-11-20T06:04:58ZengMDPI AGMaterials1996-19442020-07-011313303710.3390/ma13133037Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of <i>N</i>,<i>N</i>′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver NanoparticlesPaulina Teper0Anna Sotirova1Violeta Mitova2Natalia Oleszko-Torbus3Alicja Utrata-Wesołek4Neli Koseva5Agnieszka Kowalczuk6Barbara Mendrek7Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, PolandStephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Georgi Bonchev Str. 26, 1113 Sofia, BulgariaInstitute of Polymers, Bulgarian Academy of Sciences, Georgi Bonchev Str. Bl. 103A, 1113 Sofia, BulgariaCentre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, PolandCentre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, PolandInstitute of Polymers, Bulgarian Academy of Sciences, Georgi Bonchev Str. Bl. 103A, 1113 Sofia, BulgariaCentre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, PolandCentre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, PolandWell-defined linear and multi-arm star polymer structures were used as the templates for in situ synthesis and stabilization of silver nanoparticles (AgNPs). This approach led to hybrid nanomaterials with high stability and antibacterial activity to both Gram-positive and Gram-negative bacterial strains. The ecologically friendly so called “green” synthesis of nanomaterials was performed through AgNPs preparation in the aqueous solutions of star and linear poly(<i>N</i>,<i>N</i>′-dimethylaminoethyl methacrylate)s (PDMAEMAs); the process was followed with time. The size, shape, and zeta potential of the obtained hybrids were determined. To our knowledge, this is the first time that the antibacterial activity of PDMAEMA hybrid nanomaterial against <i>Bacillus subtilis</i>, <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> was investigated and assessed by minimum inhibitory concentration (MIC) and minimum biocidal concentration (MBC). Completely quaternized with ethyl bromide, star and linear PDMAEMAs were used in comparative biological tests. The modification of the polymers with in situ-formed AgNPs increased the antibacterial properties against all studied strains of bacteria by several times in comparison to non-modified polymers and quaternized polymers. These results yield novel nanohybrid materials that can be useful for applications in medicine and biology.https://www.mdpi.com/1996-1944/13/13/3037star polymersantimicrobial activitypoly(<i>N</i>,<i>N</i>′-dimethylaminoethyl methacrylate)silver nanoparticles |
| spellingShingle | Paulina Teper Anna Sotirova Violeta Mitova Natalia Oleszko-Torbus Alicja Utrata-Wesołek Neli Koseva Agnieszka Kowalczuk Barbara Mendrek Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of <i>N</i>,<i>N</i>′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles Materials star polymers antimicrobial activity poly(<i>N</i>,<i>N</i>′-dimethylaminoethyl methacrylate) silver nanoparticles |
| title | Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of <i>N</i>,<i>N</i>′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles |
| title_full | Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of <i>N</i>,<i>N</i>′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles |
| title_fullStr | Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of <i>N</i>,<i>N</i>′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles |
| title_full_unstemmed | Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of <i>N</i>,<i>N</i>′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles |
| title_short | Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of <i>N</i>,<i>N</i>′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles |
| title_sort | antimicrobial activity of hybrid nanomaterials based on star and linear polymers of i n i i n i dimethylaminoethyl methacrylate with in situ produced silver nanoparticles |
| topic | star polymers antimicrobial activity poly(<i>N</i>,<i>N</i>′-dimethylaminoethyl methacrylate) silver nanoparticles |
| url | https://www.mdpi.com/1996-1944/13/13/3037 |
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