Association of Clinical and Radiological Features with Disease Severity of Symptomatic Immune Checkpoint Inhibitor-Related Pneumonitis
Objectives: To investigate the predictive ability of clinical and chest computed tomography (CT) features to predict the severity of symptomatic immune checkpoint inhibitor-related pneumonitis (CIP). Methods: This study included 34 patients diagnosed with symptomatic CIP (grades 2–5) and divided int...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/4/691 |
| _version_ | 1797621535733710848 |
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| author | Qian Zhang Xiuli Tao Shijun Zhao Ning Li Shuhang Wang Ning Wu |
| author_facet | Qian Zhang Xiuli Tao Shijun Zhao Ning Li Shuhang Wang Ning Wu |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | Objectives: To investigate the predictive ability of clinical and chest computed tomography (CT) features to predict the severity of symptomatic immune checkpoint inhibitor-related pneumonitis (CIP). Methods: This study included 34 patients diagnosed with symptomatic CIP (grades 2–5) and divided into mild (grade 2) and severe CIP (grades 3–5) groups. The groups’ clinical and chest CT features were analyzed. Three manual scores (extent, image finding, and clinical symptom scores) were conducted to evaluate the diagnostic performance alone and in combination. Results: There were 20 cases of mild CIP and 14 cases of severe CIP. More severe CIP occurred within 3 months than after 3 months (11 vs. 3 cases, <i>p</i> = 0.038). Severe CIP was significantly associated with fever (<i>p</i> < 0.001) and the acute interstitial pneumonia/acute respiratory distress syndrome pattern (<i>p</i> = 0.001). The diagnostic performance of chest CT scores (extent score and image finding score) was better than that of clinical symptom score. The combination of the three scores demonstrated the best diagnostic value, with an area under the receiver operating characteristic curve of 0.948. Conclusions: The clinical and chest CT features have important application value in assessing the disease severity of symptomatic CIP. We recommend the routine use of chest CT in a comprehensive clinical evaluation. |
| first_indexed | 2024-03-11T08:57:24Z |
| format | Article |
| id | doaj.art-def18a1246064a70addbad1ebef58341 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T08:57:24Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-def18a1246064a70addbad1ebef583412023-11-16T20:01:35ZengMDPI AGDiagnostics2075-44182023-02-0113469110.3390/diagnostics13040691Association of Clinical and Radiological Features with Disease Severity of Symptomatic Immune Checkpoint Inhibitor-Related PneumonitisQian Zhang0Xiuli Tao1Shijun Zhao2Ning Li3Shuhang Wang4Ning Wu5Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Nuclear Medicine (PET-CT Center), National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaObjectives: To investigate the predictive ability of clinical and chest computed tomography (CT) features to predict the severity of symptomatic immune checkpoint inhibitor-related pneumonitis (CIP). Methods: This study included 34 patients diagnosed with symptomatic CIP (grades 2–5) and divided into mild (grade 2) and severe CIP (grades 3–5) groups. The groups’ clinical and chest CT features were analyzed. Three manual scores (extent, image finding, and clinical symptom scores) were conducted to evaluate the diagnostic performance alone and in combination. Results: There were 20 cases of mild CIP and 14 cases of severe CIP. More severe CIP occurred within 3 months than after 3 months (11 vs. 3 cases, <i>p</i> = 0.038). Severe CIP was significantly associated with fever (<i>p</i> < 0.001) and the acute interstitial pneumonia/acute respiratory distress syndrome pattern (<i>p</i> = 0.001). The diagnostic performance of chest CT scores (extent score and image finding score) was better than that of clinical symptom score. The combination of the three scores demonstrated the best diagnostic value, with an area under the receiver operating characteristic curve of 0.948. Conclusions: The clinical and chest CT features have important application value in assessing the disease severity of symptomatic CIP. We recommend the routine use of chest CT in a comprehensive clinical evaluation.https://www.mdpi.com/2075-4418/13/4/691immune checkpoint inhibitorscheckpoint inhibitor-related pneumonitisdrug toxicitycomputed tomography |
| spellingShingle | Qian Zhang Xiuli Tao Shijun Zhao Ning Li Shuhang Wang Ning Wu Association of Clinical and Radiological Features with Disease Severity of Symptomatic Immune Checkpoint Inhibitor-Related Pneumonitis Diagnostics immune checkpoint inhibitors checkpoint inhibitor-related pneumonitis drug toxicity computed tomography |
| title | Association of Clinical and Radiological Features with Disease Severity of Symptomatic Immune Checkpoint Inhibitor-Related Pneumonitis |
| title_full | Association of Clinical and Radiological Features with Disease Severity of Symptomatic Immune Checkpoint Inhibitor-Related Pneumonitis |
| title_fullStr | Association of Clinical and Radiological Features with Disease Severity of Symptomatic Immune Checkpoint Inhibitor-Related Pneumonitis |
| title_full_unstemmed | Association of Clinical and Radiological Features with Disease Severity of Symptomatic Immune Checkpoint Inhibitor-Related Pneumonitis |
| title_short | Association of Clinical and Radiological Features with Disease Severity of Symptomatic Immune Checkpoint Inhibitor-Related Pneumonitis |
| title_sort | association of clinical and radiological features with disease severity of symptomatic immune checkpoint inhibitor related pneumonitis |
| topic | immune checkpoint inhibitors checkpoint inhibitor-related pneumonitis drug toxicity computed tomography |
| url | https://www.mdpi.com/2075-4418/13/4/691 |
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