Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans
Pupil dilation in response to unexpected stimuli has been well documented in human as well as in non-human primates; however, this phenomenon has not been systematically compared between the species. This analogy is also crucial for the role of non-human primates as an animal model to investigate ne...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2021.754604/full |
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| author | Elena Selezneva Michael Brosch Sanchit Rathi T. Vighneshvel Nicole Wetzel Nicole Wetzel Nicole Wetzel |
| author_facet | Elena Selezneva Michael Brosch Sanchit Rathi T. Vighneshvel Nicole Wetzel Nicole Wetzel Nicole Wetzel |
| author_sort | Elena Selezneva |
| collection | DOAJ |
| description | Pupil dilation in response to unexpected stimuli has been well documented in human as well as in non-human primates; however, this phenomenon has not been systematically compared between the species. This analogy is also crucial for the role of non-human primates as an animal model to investigate neural mechanisms underlying the processing of unexpected stimuli and their evoked pupil dilation response. To assess this qualitatively, we used an auditory oddball paradigm in which we presented subjects a sequence of the same sounds followed by occasional deviants while we measured their evoked pupil dilation response (PDR). We used deviants (a frequency deviant, a pink noise burst, a monkey vocalization and a whistle sound) which differed in the spectral composition and in their ability to induce arousal from the standard. Most deviants elicited a significant pupil dilation in both species with decreased peak latency and increased peak amplitude in monkeys compared to humans. A temporal Principal Component Analysis (PCA) revealed two components underlying the PDRs in both species. The early component is likely associated to the parasympathetic nervous system and the late component to the sympathetic nervous system, respectively. Taken together, the present study demonstrates a qualitative similarity between PDRs to unexpected auditory stimuli in macaque and human subjects suggesting that macaques can be a suitable model for investigating the neuronal bases of pupil dilation. However, the quantitative differences in PDRs between species need to be investigated in further comparative studies. |
| first_indexed | 2024-12-24T11:15:16Z |
| format | Article |
| id | doaj.art-def271cb57f5435ebc298dd36b204d00 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-24T11:15:16Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-def271cb57f5435ebc298dd36b204d002022-12-21T16:58:24ZengFrontiers Media S.A.Frontiers in Psychology1664-10782021-12-011210.3389/fpsyg.2021.754604754604Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and HumansElena Selezneva0Michael Brosch1Sanchit Rathi2T. Vighneshvel3Nicole Wetzel4Nicole Wetzel5Nicole Wetzel6Research Group Neurocognitive Development, Leibniz Institute for Neurobiology, Magdeburg, GermanyResearch Group Comparative Neuroscience, Leibniz Institute for Neurobiology, Magdeburg, GermanyResearch Group Comparative Neuroscience, Leibniz Institute for Neurobiology, Magdeburg, GermanyResearch Group Comparative Neuroscience, Leibniz Institute for Neurobiology, Magdeburg, GermanyResearch Group Neurocognitive Development, Leibniz Institute for Neurobiology, Magdeburg, GermanyCenter for Behavioral Brain Sciences, Otto-von-Guericke University, Magdeburg, GermanyDepartment of Applied Human Sciences, Magdeburg-Stendal University of Applied Sciences, Magdeburg, GermanyPupil dilation in response to unexpected stimuli has been well documented in human as well as in non-human primates; however, this phenomenon has not been systematically compared between the species. This analogy is also crucial for the role of non-human primates as an animal model to investigate neural mechanisms underlying the processing of unexpected stimuli and their evoked pupil dilation response. To assess this qualitatively, we used an auditory oddball paradigm in which we presented subjects a sequence of the same sounds followed by occasional deviants while we measured their evoked pupil dilation response (PDR). We used deviants (a frequency deviant, a pink noise burst, a monkey vocalization and a whistle sound) which differed in the spectral composition and in their ability to induce arousal from the standard. Most deviants elicited a significant pupil dilation in both species with decreased peak latency and increased peak amplitude in monkeys compared to humans. A temporal Principal Component Analysis (PCA) revealed two components underlying the PDRs in both species. The early component is likely associated to the parasympathetic nervous system and the late component to the sympathetic nervous system, respectively. Taken together, the present study demonstrates a qualitative similarity between PDRs to unexpected auditory stimuli in macaque and human subjects suggesting that macaques can be a suitable model for investigating the neuronal bases of pupil dilation. However, the quantitative differences in PDRs between species need to be investigated in further comparative studies.https://www.frontiersin.org/articles/10.3389/fpsyg.2021.754604/fullpupillometrynon-human primatedeviantoddballauditory |
| spellingShingle | Elena Selezneva Michael Brosch Sanchit Rathi T. Vighneshvel Nicole Wetzel Nicole Wetzel Nicole Wetzel Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans Frontiers in Psychology pupillometry non-human primate deviant oddball auditory |
| title | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
| title_full | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
| title_fullStr | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
| title_full_unstemmed | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
| title_short | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
| title_sort | comparison of pupil dilation responses to unexpected sounds in monkeys and humans |
| topic | pupillometry non-human primate deviant oddball auditory |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2021.754604/full |
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