<i>N</i>-[3-(Chloromethyl)-1,2-benzisoxazol-5-yl]acetamide
Functionally substituted 1,2-benzisoxazoles are very important and promising heterocycles with various pharmacological activities. Benzoxazoles containing reactive 3-chloromethyl and 5-amino groups are practically unexplored derivatives in this series. In this communication, the simple method for th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2022/2/M1389 |
| _version_ | 1797484164282318848 |
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| author | Evgeniy N. Khodot Oleg A. Rakitin |
| author_facet | Evgeniy N. Khodot Oleg A. Rakitin |
| author_sort | Evgeniy N. Khodot |
| collection | DOAJ |
| description | Functionally substituted 1,2-benzisoxazoles are very important and promising heterocycles with various pharmacological activities. Benzoxazoles containing reactive 3-chloromethyl and 5-amino groups are practically unexplored derivatives in this series. In this communication, the simple method for the synthesis of <i>N</i>-[3-(chloromethyl)-1,2-benzisoxazol-5-yl]acetamide which is an interesting precursor for the preparation of a series of 3,5-disubstituted benzoxazoles was described. The structure of the synthesized compound was established by elemental analysis, high-resolution mass spectrometry, <sup>1</sup>H, <sup>13</sup>C NMR and IR spectroscopy, and mass spectrometry. |
| first_indexed | 2024-03-09T22:57:34Z |
| format | Article |
| id | doaj.art-def2a7688cc048fb82f1d248b0378c4a |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-09T22:57:34Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-def2a7688cc048fb82f1d248b0378c4a2023-11-23T18:08:45ZengMDPI AGMolbank1422-85992022-06-0120222M138910.3390/M1389<i>N</i>-[3-(Chloromethyl)-1,2-benzisoxazol-5-yl]acetamideEvgeniy N. Khodot0Oleg A. Rakitin1N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, RussiaN. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, RussiaFunctionally substituted 1,2-benzisoxazoles are very important and promising heterocycles with various pharmacological activities. Benzoxazoles containing reactive 3-chloromethyl and 5-amino groups are practically unexplored derivatives in this series. In this communication, the simple method for the synthesis of <i>N</i>-[3-(chloromethyl)-1,2-benzisoxazol-5-yl]acetamide which is an interesting precursor for the preparation of a series of 3,5-disubstituted benzoxazoles was described. The structure of the synthesized compound was established by elemental analysis, high-resolution mass spectrometry, <sup>1</sup>H, <sup>13</sup>C NMR and IR spectroscopy, and mass spectrometry.https://www.mdpi.com/1422-8599/2022/2/M13891,2-benzisoxazolessynthesis<i>N</i>-[3-(chloromethyl)-1,2-benzisoxazol-5-yl]acetamidering closure |
| spellingShingle | Evgeniy N. Khodot Oleg A. Rakitin <i>N</i>-[3-(Chloromethyl)-1,2-benzisoxazol-5-yl]acetamide Molbank 1,2-benzisoxazoles synthesis <i>N</i>-[3-(chloromethyl)-1,2-benzisoxazol-5-yl]acetamide ring closure |
| title | <i>N</i>-[3-(Chloromethyl)-1,2-benzisoxazol-5-yl]acetamide |
| title_full | <i>N</i>-[3-(Chloromethyl)-1,2-benzisoxazol-5-yl]acetamide |
| title_fullStr | <i>N</i>-[3-(Chloromethyl)-1,2-benzisoxazol-5-yl]acetamide |
| title_full_unstemmed | <i>N</i>-[3-(Chloromethyl)-1,2-benzisoxazol-5-yl]acetamide |
| title_short | <i>N</i>-[3-(Chloromethyl)-1,2-benzisoxazol-5-yl]acetamide |
| title_sort | i n i 3 chloromethyl 1 2 benzisoxazol 5 yl acetamide |
| topic | 1,2-benzisoxazoles synthesis <i>N</i>-[3-(chloromethyl)-1,2-benzisoxazol-5-yl]acetamide ring closure |
| url | https://www.mdpi.com/1422-8599/2022/2/M1389 |
| work_keys_str_mv | AT evgeniynkhodot ini3chloromethyl12benzisoxazol5ylacetamide AT olegarakitin ini3chloromethyl12benzisoxazol5ylacetamide |