Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer
Abstract The deregulation of the metabolic network of cancer cells is now considered one of the characteristics of cancer. Aberrant lipid synthesis and additional lipid intake promote the rapid proliferation of cancer cells. In mammals, there are five members of the long‐chain acyl‐CoA synthase fami...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.200 |
| _version_ | 1797354977037910016 |
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| author | Linlin Zhang Xiangdong Wang |
| author_facet | Linlin Zhang Xiangdong Wang |
| author_sort | Linlin Zhang |
| collection | DOAJ |
| description | Abstract The deregulation of the metabolic network of cancer cells is now considered one of the characteristics of cancer. Aberrant lipid synthesis and additional lipid intake promote the rapid proliferation of cancer cells. In mammals, there are five members of the long‐chain acyl‐CoA synthase family involved in de novo lipid synthesis, fatty acid (FA) degradation and subsequent membrane modification. Their main function is to activate long‐chain FAs through the CoA chain link, and these conjugates are mainly used for the synthesis of triglycerides. In a variety of cancers, the expression of long‐chain acyl‐CoA synthetases (ACSLs) is different, and it also changes in different cancer subtypes. This review summarized recent research on the biological functions of ACSL, as well as recent advances in related diseases, and explored the potential therapeutic role of ACSL genes. |
| first_indexed | 2024-03-08T13:57:36Z |
| format | Article |
| id | doaj.art-def30898c8224a7a9eed1d6f9742d0ef |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-03-08T13:57:36Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-def30898c8224a7a9eed1d6f9742d0ef2024-01-15T11:50:30ZengWileyClinical and Translational Discovery2768-06222023-06-0133n/an/a10.1002/ctd2.200Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancerLinlin Zhang0Xiangdong Wang1Department of Pulmonary and Critical Care Medicine Zhongshan Hospital, Fudan University Shanghai Medical College Shanghai ChinaDepartment of Pulmonary and Critical Care Medicine Zhongshan Hospital, Fudan University Shanghai Medical College Shanghai ChinaAbstract The deregulation of the metabolic network of cancer cells is now considered one of the characteristics of cancer. Aberrant lipid synthesis and additional lipid intake promote the rapid proliferation of cancer cells. In mammals, there are five members of the long‐chain acyl‐CoA synthase family involved in de novo lipid synthesis, fatty acid (FA) degradation and subsequent membrane modification. Their main function is to activate long‐chain FAs through the CoA chain link, and these conjugates are mainly used for the synthesis of triglycerides. In a variety of cancers, the expression of long‐chain acyl‐CoA synthetases (ACSLs) is different, and it also changes in different cancer subtypes. This review summarized recent research on the biological functions of ACSL, as well as recent advances in related diseases, and explored the potential therapeutic role of ACSL genes.https://doi.org/10.1002/ctd2.200cancerfatty acidslong‐chain acyl‐CoA synthetase |
| spellingShingle | Linlin Zhang Xiangdong Wang Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer Clinical and Translational Discovery cancer fatty acids long‐chain acyl‐CoA synthetase |
| title | Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer |
| title_full | Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer |
| title_fullStr | Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer |
| title_full_unstemmed | Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer |
| title_short | Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer |
| title_sort | characteristics of long chain acyl coa synthetases in metabolism and cancer |
| topic | cancer fatty acids long‐chain acyl‐CoA synthetase |
| url | https://doi.org/10.1002/ctd2.200 |
| work_keys_str_mv | AT linlinzhang characteristicsoflongchainacylcoasynthetasesinmetabolismandcancer AT xiangdongwang characteristicsoflongchainacylcoasynthetasesinmetabolismandcancer |