Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network

Enzymes with buried active sites maintain their catalytic function via a single tunnel or tunnel network. In this study we analyzed the functionality of soluble epoxide hydrolases (sEHs) tunnel network, by comparing the overall enzyme structure with the tunnel’s shape and size. sEHs were divided int...

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Bibliographic Details
Main Authors: Karolina Mitusińska, Piotr Wojsa, Maria Bzówka, Agata Raczyńska, Weronika Bagrowska, Aleksandra Samol, Patryk Kapica, Artur Góra
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021005225