Sevelamer-associated ischemic colitis with perforation
We present a case of an 83-year-old woman with end-stage renal disease and hyperphosphatemia treated with sevelamer carbonate, who underwent subtotal colectomy for diffuse bowel necrosis and two perforations in the transverse colon. Histologic examination revealed ischemic colitis with crystals cons...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-12-01
|
| Series: | Gastroenterology Insights |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/gi/article/view/6116 |
| _version_ | 1811227518087200768 |
|---|---|
| author | Rachel Hudacko Peter Kaye |
| author_facet | Rachel Hudacko Peter Kaye |
| author_sort | Rachel Hudacko |
| collection | DOAJ |
| description | We present a case of an 83-year-old woman with end-stage renal disease and hyperphosphatemia treated with sevelamer carbonate, who underwent subtotal colectomy for diffuse bowel necrosis and two perforations in the transverse colon. Histologic examination revealed ischemic colitis with crystals consistent with sevelamer carbonate embedded in ulcer debris and within the colonic wall in areas of transmural necrosis. This is a novel cause of drug-induced ischemic colitis with subsequent perforation that has not yet been reported in the literature. Clinicians and pathologists should be aware of the potential complications of sevelamer use and the histologic features of sevelamer-induced colonic injury. |
| first_indexed | 2024-04-12T09:43:43Z |
| format | Article |
| id | doaj.art-def3cb0280a04d74ab8ac08923349952 |
| institution | Directory Open Access Journal |
| issn | 2036-7414 2036-7422 |
| language | English |
| last_indexed | 2024-04-12T09:43:43Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastroenterology Insights |
| spelling | doaj.art-def3cb0280a04d74ab8ac089233499522022-12-22T03:38:01ZengMDPI AGGastroenterology Insights2036-74142036-74222015-12-016110.4081/gi.2015.61163263Sevelamer-associated ischemic colitis with perforationRachel Hudacko0Peter Kaye1Orange Pathology Associates PC, Middletown, NY; Good Samaritan Regional Medical Center, Suffern, NYGood Samaritan Regional Medical Center, Suffern, NY; Ramapo Valley Surgical Associates, Suffern, NYWe present a case of an 83-year-old woman with end-stage renal disease and hyperphosphatemia treated with sevelamer carbonate, who underwent subtotal colectomy for diffuse bowel necrosis and two perforations in the transverse colon. Histologic examination revealed ischemic colitis with crystals consistent with sevelamer carbonate embedded in ulcer debris and within the colonic wall in areas of transmural necrosis. This is a novel cause of drug-induced ischemic colitis with subsequent perforation that has not yet been reported in the literature. Clinicians and pathologists should be aware of the potential complications of sevelamer use and the histologic features of sevelamer-induced colonic injury.http://www.pagepress.org/journals/index.php/gi/article/view/6116Sevelamer carbonate, Renvela, ischemic colitis, chronic kidney disease, phosphate |
| spellingShingle | Rachel Hudacko Peter Kaye Sevelamer-associated ischemic colitis with perforation Gastroenterology Insights Sevelamer carbonate, Renvela, ischemic colitis, chronic kidney disease, phosphate |
| title | Sevelamer-associated ischemic colitis with perforation |
| title_full | Sevelamer-associated ischemic colitis with perforation |
| title_fullStr | Sevelamer-associated ischemic colitis with perforation |
| title_full_unstemmed | Sevelamer-associated ischemic colitis with perforation |
| title_short | Sevelamer-associated ischemic colitis with perforation |
| title_sort | sevelamer associated ischemic colitis with perforation |
| topic | Sevelamer carbonate, Renvela, ischemic colitis, chronic kidney disease, phosphate |
| url | http://www.pagepress.org/journals/index.php/gi/article/view/6116 |
| work_keys_str_mv | AT rachelhudacko sevelamerassociatedischemiccolitiswithperforation AT peterkaye sevelamerassociatedischemiccolitiswithperforation |