Using Blue Mini-LEDs as a Light Source Designed a Miniaturized Optomechanical Device for the Detection of Direct Bilirubin
Abstract This study developed a miniaturized optomechanical device (MOD) for the feasibility study of direct bilirubin in urine using high-collimation blue mini-light-emitting diodes (Mini-LEDs) as the light source. The constructed MOD used optical spectroscopy to analyze different concentrations of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-11-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11671-022-03750-z |
| _version_ | 1797759694544044032 |
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| author | Zhi Ting Ye Hsin-Ching Kuo Shen Fu Tseng Shu-Ru Chung Shang-Xuan Tsou |
| author_facet | Zhi Ting Ye Hsin-Ching Kuo Shen Fu Tseng Shu-Ru Chung Shang-Xuan Tsou |
| author_sort | Zhi Ting Ye |
| collection | DOAJ |
| description | Abstract This study developed a miniaturized optomechanical device (MOD) for the feasibility study of direct bilirubin in urine using high-collimation blue mini-light-emitting diodes (Mini-LEDs) as the light source. The constructed MOD used optical spectroscopy to analyze different concentrations of direct bilirubin using the absorbance spectrum to achieve a noninvasive method for detection. The experimental results showed that between the absorbance and different concentrations of direct bilirubin at the blue Mini-LEDs central wavelength (462 nm) was the optimum fitting wavelength; in the direct bilirubin concentration range from 0.855 to 17.1 μmol/L, the coefficient of determination (R 2) was 0.9999, the limit of detection (LOD) of 0.171 μmol/L, and the limit of quantitation (LOQ) of 0.570 μmol/L. Therefore, we propose using blue Mini-LEDs as a light source to design a MOD to replace the invasive blood sampling method with a spectroscopic detection of direct bilirubin concentration corresponding to absorbance. |
| first_indexed | 2024-03-12T18:48:06Z |
| format | Article |
| id | doaj.art-def5b278b5f74a71885c63d9016ffcc3 |
| institution | Directory Open Access Journal |
| issn | 1556-276X |
| language | English |
| last_indexed | 2024-03-12T18:48:06Z |
| publishDate | 2022-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-def5b278b5f74a71885c63d9016ffcc32023-08-02T07:31:42ZengSpringerOpenNanoscale Research Letters1556-276X2022-11-011711910.1186/s11671-022-03750-zUsing Blue Mini-LEDs as a Light Source Designed a Miniaturized Optomechanical Device for the Detection of Direct BilirubinZhi Ting Ye0Hsin-Ching Kuo1Shen Fu Tseng2Shu-Ru Chung3Shang-Xuan Tsou4Department of Mechanical Engineering, Advanced Institute of Manufacturing with High-Tech Innovations, National Chung Cheng UniversityDitmanson Medical Foundation Chia-Yi Christian HospitalDepartment of Mechanical Engineering, Advanced Institute of Manufacturing with High-Tech Innovations, National Chung Cheng UniversityDepartment of Materials Science and Engineering, National Formosa UniversityDepartment of Mechanical Engineering, Advanced Institute of Manufacturing with High-Tech Innovations, National Chung Cheng UniversityAbstract This study developed a miniaturized optomechanical device (MOD) for the feasibility study of direct bilirubin in urine using high-collimation blue mini-light-emitting diodes (Mini-LEDs) as the light source. The constructed MOD used optical spectroscopy to analyze different concentrations of direct bilirubin using the absorbance spectrum to achieve a noninvasive method for detection. The experimental results showed that between the absorbance and different concentrations of direct bilirubin at the blue Mini-LEDs central wavelength (462 nm) was the optimum fitting wavelength; in the direct bilirubin concentration range from 0.855 to 17.1 μmol/L, the coefficient of determination (R 2) was 0.9999, the limit of detection (LOD) of 0.171 μmol/L, and the limit of quantitation (LOQ) of 0.570 μmol/L. Therefore, we propose using blue Mini-LEDs as a light source to design a MOD to replace the invasive blood sampling method with a spectroscopic detection of direct bilirubin concentration corresponding to absorbance.https://doi.org/10.1186/s11671-022-03750-zBlue Mini-LEDsMiniaturized optomechanicalNoninvasiveDirect bilirubinQuantitative analysisCoefficient of determination |
| spellingShingle | Zhi Ting Ye Hsin-Ching Kuo Shen Fu Tseng Shu-Ru Chung Shang-Xuan Tsou Using Blue Mini-LEDs as a Light Source Designed a Miniaturized Optomechanical Device for the Detection of Direct Bilirubin Nanoscale Research Letters Blue Mini-LEDs Miniaturized optomechanical Noninvasive Direct bilirubin Quantitative analysis Coefficient of determination |
| title | Using Blue Mini-LEDs as a Light Source Designed a Miniaturized Optomechanical Device for the Detection of Direct Bilirubin |
| title_full | Using Blue Mini-LEDs as a Light Source Designed a Miniaturized Optomechanical Device for the Detection of Direct Bilirubin |
| title_fullStr | Using Blue Mini-LEDs as a Light Source Designed a Miniaturized Optomechanical Device for the Detection of Direct Bilirubin |
| title_full_unstemmed | Using Blue Mini-LEDs as a Light Source Designed a Miniaturized Optomechanical Device for the Detection of Direct Bilirubin |
| title_short | Using Blue Mini-LEDs as a Light Source Designed a Miniaturized Optomechanical Device for the Detection of Direct Bilirubin |
| title_sort | using blue mini leds as a light source designed a miniaturized optomechanical device for the detection of direct bilirubin |
| topic | Blue Mini-LEDs Miniaturized optomechanical Noninvasive Direct bilirubin Quantitative analysis Coefficient of determination |
| url | https://doi.org/10.1186/s11671-022-03750-z |
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