Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome
The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/1/78 |
| _version_ | 1797496267874500608 |
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| author | Cristina Mas-Bargues Matilde Alique María Teresa Barrús-Ortiz Consuelo Borrás Raquel Rodrigues-Díez |
| author_facet | Cristina Mas-Bargues Matilde Alique María Teresa Barrús-Ortiz Consuelo Borrás Raquel Rodrigues-Díez |
| author_sort | Cristina Mas-Bargues |
| collection | DOAJ |
| description | The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in the development and progression of both aging and chronic diseases, opening the door to the discovery of new underlying mechanisms and signaling pathways. Among them, senolytics and senomorphics, and extracellular vesicles offer new therapeutic strategies to slow the development of aging and its associated chronic diseases by decreasing oxidative stress. In this review, we aim to discuss the role of extracellular vesicles in human cardiorenal syndrome development and their possible role as biomarkers, targets, or vehicles of drugs to treat this syndrome. |
| first_indexed | 2024-03-10T03:01:13Z |
| format | Article |
| id | doaj.art-def650adc04448e39ad74148f537e6ab |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T03:01:13Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-def650adc04448e39ad74148f537e6ab2023-11-23T12:46:59ZengMDPI AGAntioxidants2076-39212021-12-011117810.3390/antiox11010078Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal SyndromeCristina Mas-Bargues0Matilde Alique1María Teresa Barrús-Ortiz2Consuelo Borrás3Raquel Rodrigues-Díez4Grupo de Investigación Freshage, Departmento de Fisiología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, SpainDepartamento de Biología de Sistemas, Universidad de Alcalá, 28871 Madrid, SpainÁrea de Fisiología, Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Univesidad Rey Juan Carlos, Avenida de Atenas s/n, 28922 Madrid, SpainGrupo de Investigación Freshage, Departmento de Fisiología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, SpainDepartamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainThe incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in the development and progression of both aging and chronic diseases, opening the door to the discovery of new underlying mechanisms and signaling pathways. Among them, senolytics and senomorphics, and extracellular vesicles offer new therapeutic strategies to slow the development of aging and its associated chronic diseases by decreasing oxidative stress. In this review, we aim to discuss the role of extracellular vesicles in human cardiorenal syndrome development and their possible role as biomarkers, targets, or vehicles of drugs to treat this syndrome.https://www.mdpi.com/2076-3921/11/1/78agingoxidative stresssenescenceextracellular vesiclessenolyticsinflammation |
| spellingShingle | Cristina Mas-Bargues Matilde Alique María Teresa Barrús-Ortiz Consuelo Borrás Raquel Rodrigues-Díez Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome Antioxidants aging oxidative stress senescence extracellular vesicles senolytics inflammation |
| title | Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome |
| title_full | Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome |
| title_fullStr | Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome |
| title_full_unstemmed | Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome |
| title_short | Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome |
| title_sort | exploring new kingdoms the role of extracellular vesicles in oxi inflamm aging related to cardiorenal syndrome |
| topic | aging oxidative stress senescence extracellular vesicles senolytics inflammation |
| url | https://www.mdpi.com/2076-3921/11/1/78 |
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