Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study
BackgroundThe safety of COVID-19 vaccines has been clarified in clinical trials; however, some immunocompromised patients, such as myasthenia gravis (MG) patients, are still hesitant to receive vaccines. Whether COVID-19 vaccination increases the risk of disease worsening in these patients remains u...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1141983/full |
| _version_ | 1827952356656939008 |
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| author | Zhe Ruan Xiao Huan Yue Su Yong-Lan Tang Dong-Dong Meng Da-Lin Ren Chun-Hong Li Si-Jia Hao Chong-Bo Zhao Su-Shan Luo Zhu-Yi Li Ting Chang |
| author_facet | Zhe Ruan Xiao Huan Yue Su Yong-Lan Tang Dong-Dong Meng Da-Lin Ren Chun-Hong Li Si-Jia Hao Chong-Bo Zhao Su-Shan Luo Zhu-Yi Li Ting Chang |
| author_sort | Zhe Ruan |
| collection | DOAJ |
| description | BackgroundThe safety of COVID-19 vaccines has been clarified in clinical trials; however, some immunocompromised patients, such as myasthenia gravis (MG) patients, are still hesitant to receive vaccines. Whether COVID-19 vaccination increases the risk of disease worsening in these patients remains unknown. This study aims to evaluate the risk of disease exacerbation in COVID-19-vaccinated MG patients.MethodsThe data in this study were collected from the MG database at Tangdu Hospital, the Fourth Military Medical University, and the Tertiary Referral Diagnostic Center at Huashan Hospital, Fudan University, from 1 April 2022 to 31 October 2022. A self-controlled case series method was applied, and the incidence rate ratios were calculated in the prespecified risk period using conditional Poisson regression.ResultsInactivated COVID-19 vaccines did not increase the risk of disease exacerbation in MG patients with stable disease status. A few patients experienced transient disease worsening, but the symptoms were mild. It is noted that more attention should be paid to thymoma-related MG, especially within 1 week after COVID-19 vaccination.ConclusionCOVID-19 vaccination has no long-term impact on MG relapse. |
| first_indexed | 2024-04-09T13:56:08Z |
| format | Article |
| id | doaj.art-def6ada8be704eff815dcaa49000fefa |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T13:56:08Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-def6ada8be704eff815dcaa49000fefa2023-05-08T04:55:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11419831141983Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series studyZhe Ruan0Xiao Huan1Yue Su2Yong-Lan Tang3Dong-Dong Meng4Da-Lin Ren5Chun-Hong Li6Si-Jia Hao7Chong-Bo Zhao8Su-Shan Luo9Zhu-Yi Li10Ting Chang11Department of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaHuashan Rare Disease Center, Department of Neurology, Huashan Hospital Fudan University, Shanghai, ChinaDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Experimental Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Experimental Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaHuashan Rare Disease Center, Department of Neurology, Huashan Hospital Fudan University, Shanghai, ChinaHuashan Rare Disease Center, Department of Neurology, Huashan Hospital Fudan University, Shanghai, ChinaDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaBackgroundThe safety of COVID-19 vaccines has been clarified in clinical trials; however, some immunocompromised patients, such as myasthenia gravis (MG) patients, are still hesitant to receive vaccines. Whether COVID-19 vaccination increases the risk of disease worsening in these patients remains unknown. This study aims to evaluate the risk of disease exacerbation in COVID-19-vaccinated MG patients.MethodsThe data in this study were collected from the MG database at Tangdu Hospital, the Fourth Military Medical University, and the Tertiary Referral Diagnostic Center at Huashan Hospital, Fudan University, from 1 April 2022 to 31 October 2022. A self-controlled case series method was applied, and the incidence rate ratios were calculated in the prespecified risk period using conditional Poisson regression.ResultsInactivated COVID-19 vaccines did not increase the risk of disease exacerbation in MG patients with stable disease status. A few patients experienced transient disease worsening, but the symptoms were mild. It is noted that more attention should be paid to thymoma-related MG, especially within 1 week after COVID-19 vaccination.ConclusionCOVID-19 vaccination has no long-term impact on MG relapse.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1141983/fullmyasthenia gravisCOVID-19 vaccinesvaccine hesitancyself-control studyvaccine safety |
| spellingShingle | Zhe Ruan Xiao Huan Yue Su Yong-Lan Tang Dong-Dong Meng Da-Lin Ren Chun-Hong Li Si-Jia Hao Chong-Bo Zhao Su-Shan Luo Zhu-Yi Li Ting Chang Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study Frontiers in Immunology myasthenia gravis COVID-19 vaccines vaccine hesitancy self-control study vaccine safety |
| title | Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study |
| title_full | Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study |
| title_fullStr | Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study |
| title_full_unstemmed | Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study |
| title_short | Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study |
| title_sort | safety of covid 19 vaccine in patients with myasthenia gravis a self controlled case series study |
| topic | myasthenia gravis COVID-19 vaccines vaccine hesitancy self-control study vaccine safety |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1141983/full |
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