Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-Analysis
Ilheus fever is a mosquito-borne, poorly known tropical disease. We aimed to report the pooled rate of exposure to the Ilheus virus (ILHV) and clinical outcomes of infection to determine the epidemiological patterns of ILHV. We conducted a meta-analysis of 37 studies (<i>n</i> = 17,722 i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/1/92 |
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| author | Vivaldo Gomes da Costa Marielena Vogel Saivish Nikolas Alexander Borsato Lino Cíntia Bittar Marília de Freitas Calmon Maurício Lacerda Nogueira Paula Rahal |
| author_facet | Vivaldo Gomes da Costa Marielena Vogel Saivish Nikolas Alexander Borsato Lino Cíntia Bittar Marília de Freitas Calmon Maurício Lacerda Nogueira Paula Rahal |
| author_sort | Vivaldo Gomes da Costa |
| collection | DOAJ |
| description | Ilheus fever is a mosquito-borne, poorly known tropical disease. We aimed to report the pooled rate of exposure to the Ilheus virus (ILHV) and clinical outcomes of infection to determine the epidemiological patterns of ILHV. We conducted a meta-analysis of 37 studies (<i>n</i> = 17,722 individuals) from Latin America. The common clinical characteristics of ILHV infection were fever (82.3%), headache (52.9%), and myalgia (52.9%). Encephalitis complicated the course of the infection in 29.4% cases. Monotypic serological reactions detected a pooled rate of exposure of 2% to ILHV (95% CI: 1–2). Studies were mainly conducted in Brazil, with a pooled proportion of ILHV positivity of 8% (95% CI: 3–14). Males (12%) had higher rates of seropositivity than females (7%) and had high chances of ILHV infection (OR: 1.7, 95% CI: 1.2–2.5). Seropositivity increased with age, from 2% (95% CI: 2–3) among people aged 0–14 years to 8% (95% CI: 6–10) among people aged 15–64 years. Our analysis indicated a low and relatively constant burden of ILHV in Latin America. More research is needed to evaluate and innovate serological assays for ILHV to better estimate the burden and dynamics of epidemiological changes in ILHV infection in different regions. |
| first_indexed | 2024-03-09T11:02:38Z |
| format | Article |
| id | doaj.art-def92fd10ed24afabdb47314e843fa7f |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T11:02:38Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-def92fd10ed24afabdb47314e843fa7f2023-12-01T01:09:42ZengMDPI AGViruses1999-49152022-12-011519210.3390/v15010092Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-AnalysisVivaldo Gomes da Costa0Marielena Vogel Saivish1Nikolas Alexander Borsato Lino2Cíntia Bittar3Marília de Freitas Calmon4Maurício Lacerda Nogueira5Paula Rahal6Laboratório de Estudos Genômicos, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista (UNESP), São José do Rio Preto 15054-000, BrazilLaboratório de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, BrazilLaboratório de Estudos Genômicos, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista (UNESP), São José do Rio Preto 15054-000, BrazilLaboratório de Estudos Genômicos, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista (UNESP), São José do Rio Preto 15054-000, BrazilLaboratório de Estudos Genômicos, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista (UNESP), São José do Rio Preto 15054-000, BrazilLaboratório de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, BrazilLaboratório de Estudos Genômicos, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista (UNESP), São José do Rio Preto 15054-000, BrazilIlheus fever is a mosquito-borne, poorly known tropical disease. We aimed to report the pooled rate of exposure to the Ilheus virus (ILHV) and clinical outcomes of infection to determine the epidemiological patterns of ILHV. We conducted a meta-analysis of 37 studies (<i>n</i> = 17,722 individuals) from Latin America. The common clinical characteristics of ILHV infection were fever (82.3%), headache (52.9%), and myalgia (52.9%). Encephalitis complicated the course of the infection in 29.4% cases. Monotypic serological reactions detected a pooled rate of exposure of 2% to ILHV (95% CI: 1–2). Studies were mainly conducted in Brazil, with a pooled proportion of ILHV positivity of 8% (95% CI: 3–14). Males (12%) had higher rates of seropositivity than females (7%) and had high chances of ILHV infection (OR: 1.7, 95% CI: 1.2–2.5). Seropositivity increased with age, from 2% (95% CI: 2–3) among people aged 0–14 years to 8% (95% CI: 6–10) among people aged 15–64 years. Our analysis indicated a low and relatively constant burden of ILHV in Latin America. More research is needed to evaluate and innovate serological assays for ILHV to better estimate the burden and dynamics of epidemiological changes in ILHV infection in different regions.https://www.mdpi.com/1999-4915/15/1/92Ilheus virusarbovirusneglected diseasemeta-analysissero-epidemiology |
| spellingShingle | Vivaldo Gomes da Costa Marielena Vogel Saivish Nikolas Alexander Borsato Lino Cíntia Bittar Marília de Freitas Calmon Maurício Lacerda Nogueira Paula Rahal Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-Analysis Viruses Ilheus virus arbovirus neglected disease meta-analysis sero-epidemiology |
| title | Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-Analysis |
| title_full | Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-Analysis |
| title_fullStr | Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-Analysis |
| title_full_unstemmed | Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-Analysis |
| title_short | Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-Analysis |
| title_sort | clinical landscape and rate of exposure to ilheus virus insights from systematic review and meta analysis |
| topic | Ilheus virus arbovirus neglected disease meta-analysis sero-epidemiology |
| url | https://www.mdpi.com/1999-4915/15/1/92 |
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