Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease
Objectives: The study aimed to examine the association of three anemia-related biomarkers with the adequacy of peritoneal dialysis (PD) in patients with chronic kidney disease (CKD).Methods: This study included 127 PD patients. The total Kt/V urea (Kt/V) was calculated according to the Kidney Diseas...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1170537/full |
| _version_ | 1797771123203506176 |
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| author | Jia-Lin Li Zhen Cai Jing Zhao Xiang-Gang Zhu Qian Li Yan-Shuang Li Meng-Chao Liu Fang-Qiang Cui Wen-Jing Zhao Wen-Quan Niu |
| author_facet | Jia-Lin Li Zhen Cai Jing Zhao Xiang-Gang Zhu Qian Li Yan-Shuang Li Meng-Chao Liu Fang-Qiang Cui Wen-Jing Zhao Wen-Quan Niu |
| author_sort | Jia-Lin Li |
| collection | DOAJ |
| description | Objectives: The study aimed to examine the association of three anemia-related biomarkers with the adequacy of peritoneal dialysis (PD) in patients with chronic kidney disease (CKD).Methods: This study included 127 PD patients. The total Kt/V urea (Kt/V) was calculated according to the Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines. All patients were classified into two groups based on Kt/V, viz., adequate (Kt/V ≥1.7) and inadequate (Kt/V <1.7) groups. Effect sizes are expressed as odds ratios (ORs) and 95% confidence interval (CI).Results: After adjusting for age, gender, hypertension, diabetes, and PD duration, 20 g/L increment in hemoglobin (Hgb) was observed to significantly reduce the risk of inadequate PD by 19% (OR; 95% CI; P: 0.81; 0.70 to 0.95; 0.009), 5 g/L increment in the mean corpuscular hemoglobin concentration (MCHC) by 7% (0.93; 0.88 to 0.98; 0.009), and 5% increment in transferrin saturation (TS) by 23% (0.77; 0.64 to 0.94; 0.012). The gender-specific nomogram model was constructed by incorporating three significant anemia-related biomarkers and convenient influencing factors, and the prediction accuracy was good (concordance index (C-index): 0.686 for men and 0.825 for women).Conclusion: Our findings indicate that the deterioration of three anemia-related biomarkers (Hgb, MCHC, and TS) can precipitate the development of inadequate PD in Chinese patients with CKD. |
| first_indexed | 2024-03-12T21:32:59Z |
| format | Article |
| id | doaj.art-defc2088443d49e79dcfe2f03300b1e2 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-12T21:32:59Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-defc2088443d49e79dcfe2f03300b1e22023-07-27T17:04:47ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-07-011410.3389/fphys.2023.11705371170537Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney diseaseJia-Lin Li0Zhen Cai1Jing Zhao2Xiang-Gang Zhu3Qian Li4Yan-Shuang Li5Meng-Chao Liu6Fang-Qiang Cui7Wen-Jing Zhao8Wen-Quan Niu9Department of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaCenter for Evidence-Based Medicine, Capital Institute of Pediatrics, Beijing, ChinaObjectives: The study aimed to examine the association of three anemia-related biomarkers with the adequacy of peritoneal dialysis (PD) in patients with chronic kidney disease (CKD).Methods: This study included 127 PD patients. The total Kt/V urea (Kt/V) was calculated according to the Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines. All patients were classified into two groups based on Kt/V, viz., adequate (Kt/V ≥1.7) and inadequate (Kt/V <1.7) groups. Effect sizes are expressed as odds ratios (ORs) and 95% confidence interval (CI).Results: After adjusting for age, gender, hypertension, diabetes, and PD duration, 20 g/L increment in hemoglobin (Hgb) was observed to significantly reduce the risk of inadequate PD by 19% (OR; 95% CI; P: 0.81; 0.70 to 0.95; 0.009), 5 g/L increment in the mean corpuscular hemoglobin concentration (MCHC) by 7% (0.93; 0.88 to 0.98; 0.009), and 5% increment in transferrin saturation (TS) by 23% (0.77; 0.64 to 0.94; 0.012). The gender-specific nomogram model was constructed by incorporating three significant anemia-related biomarkers and convenient influencing factors, and the prediction accuracy was good (concordance index (C-index): 0.686 for men and 0.825 for women).Conclusion: Our findings indicate that the deterioration of three anemia-related biomarkers (Hgb, MCHC, and TS) can precipitate the development of inadequate PD in Chinese patients with CKD.https://www.frontiersin.org/articles/10.3389/fphys.2023.1170537/fullchronic kidney diseaseperitoneal dialysisKt/V ureaanemianomogram |
| spellingShingle | Jia-Lin Li Zhen Cai Jing Zhao Xiang-Gang Zhu Qian Li Yan-Shuang Li Meng-Chao Liu Fang-Qiang Cui Wen-Jing Zhao Wen-Quan Niu Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease Frontiers in Physiology chronic kidney disease peritoneal dialysis Kt/V urea anemia nomogram |
| title | Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease |
| title_full | Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease |
| title_fullStr | Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease |
| title_full_unstemmed | Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease |
| title_short | Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease |
| title_sort | association between anemia related biomarkers and the adequacy of peritoneal dialysis in chinese patients with chronic kidney disease |
| topic | chronic kidney disease peritoneal dialysis Kt/V urea anemia nomogram |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1170537/full |
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