Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudovi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/1135 |
| _version_ | 1797530360294146048 |
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| author | Benjamin Trinité Edwards Pradenas Silvia Marfil Carla Rovirosa Víctor Urrea Ferran Tarrés-Freixas Raquel Ortiz Jordi Rodon Júlia Vergara-Alert Joaquim Segalés Victor Guallar Rosalba Lepore Nuria Izquierdo-Useros Glòria Trujillo Jaume Trapé Carolina González-Fernández Antonia Flor Rafel Pérez-Vidal Ruth Toledo Anna Chamorro Roger Paredes Ignacio Blanco Eulàlia Grau Marta Massanella Jorge Carrillo Bonaventura Clotet Julià Blanco |
| author_facet | Benjamin Trinité Edwards Pradenas Silvia Marfil Carla Rovirosa Víctor Urrea Ferran Tarrés-Freixas Raquel Ortiz Jordi Rodon Júlia Vergara-Alert Joaquim Segalés Victor Guallar Rosalba Lepore Nuria Izquierdo-Useros Glòria Trujillo Jaume Trapé Carolina González-Fernández Antonia Flor Rafel Pérez-Vidal Ruth Toledo Anna Chamorro Roger Paredes Ignacio Blanco Eulàlia Grau Marta Massanella Jorge Carrillo Bonaventura Clotet Julià Blanco |
| author_sort | Benjamin Trinité |
| collection | DOAJ |
| description | With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection. |
| first_indexed | 2024-03-10T10:27:47Z |
| format | Article |
| id | doaj.art-defd453ae84846ac92fa6df368483a04 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:27:47Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-defd453ae84846ac92fa6df368483a042023-11-21T23:53:47ZengMDPI AGViruses1999-49152021-06-01136113510.3390/v13061135Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated IndividualsBenjamin Trinité0Edwards Pradenas1Silvia Marfil2Carla Rovirosa3Víctor Urrea4Ferran Tarrés-Freixas5Raquel Ortiz6Jordi Rodon7Júlia Vergara-Alert8Joaquim Segalés9Victor Guallar10Rosalba Lepore11Nuria Izquierdo-Useros12Glòria Trujillo13Jaume Trapé14Carolina González-Fernández15Antonia Flor16Rafel Pérez-Vidal17Ruth Toledo18Anna Chamorro19Roger Paredes20Ignacio Blanco21Eulàlia Grau22Marta Massanella23Jorge Carrillo24Bonaventura Clotet25Julià Blanco26IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainInstitute de Recerca i Tecnologia Agrària (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Bellaterra, SpainInstitute de Recerca i Tecnologia Agrària (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Bellaterra, SpainCentre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Autonomous University of Barcelona (UAB), 08193 Bellaterra, SpainBarcelona Supercomputing Center, 08034 Barcelona, SpainBarcelona Supercomputing Center, 08034 Barcelona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainFundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, SpainFundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, SpainFundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, SpainFundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, SpainFundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, SpainInfectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916 Badalona, SpainInfectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainGermans Trias i Pujol Hospital, 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainIrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, SpainWith the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection.https://www.mdpi.com/1999-4915/13/6/1135SARS-CoV-2humoral responsepseudovirusneutralizationB.1.1.7 variant |
| spellingShingle | Benjamin Trinité Edwards Pradenas Silvia Marfil Carla Rovirosa Víctor Urrea Ferran Tarrés-Freixas Raquel Ortiz Jordi Rodon Júlia Vergara-Alert Joaquim Segalés Victor Guallar Rosalba Lepore Nuria Izquierdo-Useros Glòria Trujillo Jaume Trapé Carolina González-Fernández Antonia Flor Rafel Pérez-Vidal Ruth Toledo Anna Chamorro Roger Paredes Ignacio Blanco Eulàlia Grau Marta Massanella Jorge Carrillo Bonaventura Clotet Julià Blanco Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals Viruses SARS-CoV-2 humoral response pseudovirus neutralization B.1.1.7 variant |
| title | Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals |
| title_full | Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals |
| title_fullStr | Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals |
| title_full_unstemmed | Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals |
| title_short | Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals |
| title_sort | previous sars cov 2 infection increases b 1 1 7 cross neutralization by vaccinated individuals |
| topic | SARS-CoV-2 humoral response pseudovirus neutralization B.1.1.7 variant |
| url | https://www.mdpi.com/1999-4915/13/6/1135 |
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