Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene.
In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was seque...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3168504?pdf=render |
| _version_ | 1819181640261304320 |
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| author | Elizabeth B Liu Leonardo Ferreyra Stephen L Fischer Jorge V Pavan Silvia V Nates Nolan Ryan Hudson Damaris Tirado David W Dyer James Chodosh Donald Seto Morris S Jones |
| author_facet | Elizabeth B Liu Leonardo Ferreyra Stephen L Fischer Jorge V Pavan Silvia V Nates Nolan Ryan Hudson Damaris Tirado David W Dyer James Chodosh Donald Seto Morris S Jones |
| author_sort | Elizabeth B Liu |
| collection | DOAJ |
| description | In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was sequenced to elucidate its origin. Bioinformatic and phylogenetic analyses of this genome demonstrate that this virus, heretofore referred to as HAdV-D58, contains a novel hexon gene as well as a recombinant fiber gene. In addition, serological analysis demonstrated that HAdV-D58 has a different neutralization profile than all previously characterized HAdVs. Bootscan analysis of the HAdV-D58 fiber gene strongly suggests one recombination event. |
| first_indexed | 2024-12-22T22:33:27Z |
| format | Article |
| id | doaj.art-deff08990c2447e68d417c1d047c57e3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T22:33:27Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-deff08990c2447e68d417c1d047c57e32022-12-21T18:10:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2449110.1371/journal.pone.0024491Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene.Elizabeth B LiuLeonardo FerreyraStephen L FischerJorge V PavanSilvia V NatesNolan Ryan HudsonDamaris TiradoDavid W DyerJames ChodoshDonald SetoMorris S JonesIn February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was sequenced to elucidate its origin. Bioinformatic and phylogenetic analyses of this genome demonstrate that this virus, heretofore referred to as HAdV-D58, contains a novel hexon gene as well as a recombinant fiber gene. In addition, serological analysis demonstrated that HAdV-D58 has a different neutralization profile than all previously characterized HAdVs. Bootscan analysis of the HAdV-D58 fiber gene strongly suggests one recombination event.http://europepmc.org/articles/PMC3168504?pdf=render |
| spellingShingle | Elizabeth B Liu Leonardo Ferreyra Stephen L Fischer Jorge V Pavan Silvia V Nates Nolan Ryan Hudson Damaris Tirado David W Dyer James Chodosh Donald Seto Morris S Jones Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene. PLoS ONE |
| title | Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene. |
| title_full | Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene. |
| title_fullStr | Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene. |
| title_full_unstemmed | Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene. |
| title_short | Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene. |
| title_sort | genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene |
| url | http://europepmc.org/articles/PMC3168504?pdf=render |
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