Mechanism of Lycium barbarum polysaccharides relieving inflammation in asthmatic mice
Objective To observe the protective effects of Lycium barbarum polysaccharides(LBPs) on lung inflammatory injury in OVA(albumin chicken egg) induced asthma mice and explore its mechanism. Methods OVAinduced allergic asthma mice model was established and mice were then treated with Lycium barabrum po...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
The Editorial Office of Chinese Journal of Food Hygiene
2021-01-01
|
| Series: | Zhongguo shipin weisheng zazhi |
| Subjects: | |
| Online Access: | http://www.zgspws.com/zgspwszz/article/abstract/20210105 |
| _version_ | 1828065230287011840 |
|---|---|
| author | Jiaqing ZHAO Chunli SHI Liying WANG Mei YIN Caixia ZHENG Yu WU Wei ZHAO Xiaoping GAO |
| author_facet | Jiaqing ZHAO Chunli SHI Liying WANG Mei YIN Caixia ZHENG Yu WU Wei ZHAO Xiaoping GAO |
| author_sort | Jiaqing ZHAO |
| collection | DOAJ |
| description | Objective To observe the protective effects of Lycium barbarum polysaccharides(LBPs) on lung inflammatory injury in OVA(albumin chicken egg) induced asthma mice and explore its mechanism. Methods OVAinduced allergic asthma mice model was established and mice were then treated with Lycium barabrum polysaccharides hematoxylin-eosin(HE) staining was used to detect lung tissue structure and inflammatory cell infiltration. Periodic acidschiff(PAS) staining was used to examine bronchial goblet cell. Masson staining were used to identify collagen deposition in lung tissues. The expression of eosinophils cells, helper T cells(Th1 cells, Th2 cells, Th17 cells) and regulatory T cells(Treg cells) in lung tissue of mice was detected by flow cytometry. Results Compared with asthma mice group, after the intervention of Lycium barbarum polysaccharides, the level of eosinophils in lung tissue of asthma mice was significantly decreased(P<0. 05), the degree of fibrosis was significantly alleviated, the metaplasia of bronchial goblet cells was significantly decreased, the levels of Th1 and Treg were up-regulated(P<0. 05), and the levels of Th2 and Th17 were down-regulated(P < 0. 05). Conclusion Lycium barbarum polysaccharide extracted from Lycium barbarum fruit ameliorates asthma in mice by reducing inflammation and modulating the balance of Th cells. |
| first_indexed | 2024-04-10T23:10:32Z |
| format | Article |
| id | doaj.art-df003346be1c433b81a832fab7a3c2aa |
| institution | Directory Open Access Journal |
| issn | 1004-8456 |
| language | zho |
| last_indexed | 2024-04-10T23:10:32Z |
| publishDate | 2021-01-01 |
| publisher | The Editorial Office of Chinese Journal of Food Hygiene |
| record_format | Article |
| series | Zhongguo shipin weisheng zazhi |
| spelling | doaj.art-df003346be1c433b81a832fab7a3c2aa2023-01-13T05:53:58ZzhoThe Editorial Office of Chinese Journal of Food HygieneZhongguo shipin weisheng zazhi1004-84562021-01-013301232810.13590/j.cjfh.2021.01.0051004-8456(2021)01-0023-06Mechanism of Lycium barbarum polysaccharides relieving inflammation in asthmatic miceJiaqing ZHAO0Chunli SHI1Liying WANG2Mei YIN3Caixia ZHENG4Yu WU5Wei ZHAO6Xiaoping GAO7Basic Medical College of Ningxia Medical University, Ningxia Yinchuan 750004, ChinaBasic Medical College of Ningxia Medical University, Ningxia Yinchuan 750004, ChinaNingxia Senmiao Goji Technology and Development Co. Ltd., Ningxia Yinchuan 750000, ChinaCardiovascular Hospital, General Hospital of Ningxia Medical University, Ningxia Yinchuan 750000, ChinaBasic Medical College of Ningxia Medical University, Ningxia Yinchuan 750004, ChinaBasic Medical College of Ningxia Medical University, Ningxia Yinchuan 750004, ChinaBasic Medical College of Ningxia Medical University, Ningxia Yinchuan 750004, ChinaGeneral Hospital of Ningxia Medical University, Ningxia Yinchuan 750004, ChinaObjective To observe the protective effects of Lycium barbarum polysaccharides(LBPs) on lung inflammatory injury in OVA(albumin chicken egg) induced asthma mice and explore its mechanism. Methods OVAinduced allergic asthma mice model was established and mice were then treated with Lycium barabrum polysaccharides hematoxylin-eosin(HE) staining was used to detect lung tissue structure and inflammatory cell infiltration. Periodic acidschiff(PAS) staining was used to examine bronchial goblet cell. Masson staining were used to identify collagen deposition in lung tissues. The expression of eosinophils cells, helper T cells(Th1 cells, Th2 cells, Th17 cells) and regulatory T cells(Treg cells) in lung tissue of mice was detected by flow cytometry. Results Compared with asthma mice group, after the intervention of Lycium barbarum polysaccharides, the level of eosinophils in lung tissue of asthma mice was significantly decreased(P<0. 05), the degree of fibrosis was significantly alleviated, the metaplasia of bronchial goblet cells was significantly decreased, the levels of Th1 and Treg were up-regulated(P<0. 05), and the levels of Th2 and Th17 were down-regulated(P < 0. 05). Conclusion Lycium barbarum polysaccharide extracted from Lycium barbarum fruit ameliorates asthma in mice by reducing inflammation and modulating the balance of Th cells.http://www.zgspws.com/zgspwszz/article/abstract/20210105lycium barbarum polysaccharidesasthmahelper t cells imbalanceimmune regulation |
| spellingShingle | Jiaqing ZHAO Chunli SHI Liying WANG Mei YIN Caixia ZHENG Yu WU Wei ZHAO Xiaoping GAO Mechanism of Lycium barbarum polysaccharides relieving inflammation in asthmatic mice Zhongguo shipin weisheng zazhi lycium barbarum polysaccharides asthma helper t cells imbalance immune regulation |
| title | Mechanism of Lycium barbarum polysaccharides relieving inflammation in asthmatic mice |
| title_full | Mechanism of Lycium barbarum polysaccharides relieving inflammation in asthmatic mice |
| title_fullStr | Mechanism of Lycium barbarum polysaccharides relieving inflammation in asthmatic mice |
| title_full_unstemmed | Mechanism of Lycium barbarum polysaccharides relieving inflammation in asthmatic mice |
| title_short | Mechanism of Lycium barbarum polysaccharides relieving inflammation in asthmatic mice |
| title_sort | mechanism of lycium barbarum polysaccharides relieving inflammation in asthmatic mice |
| topic | lycium barbarum polysaccharides asthma helper t cells imbalance immune regulation |
| url | http://www.zgspws.com/zgspwszz/article/abstract/20210105 |
| work_keys_str_mv | AT jiaqingzhao mechanismoflyciumbarbarumpolysaccharidesrelievinginflammationinasthmaticmice AT chunlishi mechanismoflyciumbarbarumpolysaccharidesrelievinginflammationinasthmaticmice AT liyingwang mechanismoflyciumbarbarumpolysaccharidesrelievinginflammationinasthmaticmice AT meiyin mechanismoflyciumbarbarumpolysaccharidesrelievinginflammationinasthmaticmice AT caixiazheng mechanismoflyciumbarbarumpolysaccharidesrelievinginflammationinasthmaticmice AT yuwu mechanismoflyciumbarbarumpolysaccharidesrelievinginflammationinasthmaticmice AT weizhao mechanismoflyciumbarbarumpolysaccharidesrelievinginflammationinasthmaticmice AT xiaopinggao mechanismoflyciumbarbarumpolysaccharidesrelievinginflammationinasthmaticmice |