Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease
Abstract Triglyceride–glucose (TyG) index has been proposed to be a simple, economical, and reliable marker of insulin resistance. We aimed to investigate whether TyG is an independent predictor of hyperuricemia in diabetic kidney disease (DKD) populations by conducting a cross-sectional and longitu...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23478-1 |
| _version_ | 1797986675004014592 |
|---|---|
| author | Qiuhong Li Xian Shao Saijun Zhou Zhuang Cui Hongyan Liu Tongdan Wang Xiaoguang Fan Pei Yu |
| author_facet | Qiuhong Li Xian Shao Saijun Zhou Zhuang Cui Hongyan Liu Tongdan Wang Xiaoguang Fan Pei Yu |
| author_sort | Qiuhong Li |
| collection | DOAJ |
| description | Abstract Triglyceride–glucose (TyG) index has been proposed to be a simple, economical, and reliable marker of insulin resistance. We aimed to investigate whether TyG is an independent predictor of hyperuricemia in diabetic kidney disease (DKD) populations by conducting a cross-sectional and longitudinal study. A total of 6,471 patients were enrolled in cross-sectional analysis, and 3,634 patients without hyperuricemia at the baseline were included in longitudinal analysis and were followed up for a median of 23.0 months. Hyperuricemia was categorized as a serum uric acid level ≥ 420 umol/L (7 mg/dL). In this study, 19.58% of participants had hyperuricemia. In the cross-sectional analysis, multivariate logistics regression analysis showed that the ORs (95% CI) for hyperuricemia in the second, third, and fourth TyG quartiles were 1.40 (95% CI 0.73–2.65), 1.69 (95% CI 0.90–3.18), and 4.53 (95% CI 2.39–8.57), respectively, compared with the first quartile. Longitudinally, the Kaplan–Meier survival analysis showed that higher TyG levels predicted higher incidence of hyperuricemia. Multivariate Cox regression model revealed that the hazard ratios for hyperuricemia in the upper quartiles of the TyG index were 1.69 (95% CI 0.97–2.93), 2.23 (95% CI 1.33–3.75), and 2.50 (95% CI 1.46–4.27), respectively, compared with the first quartile. Moreover, the subgroup analyses revealed that the relationship between TyG levels and hyperuricemia was robust in DKD patients. Our findings indicate a significant independent correlation between the TyG index and the risk of hyperuricemia in DKD patients. |
| first_indexed | 2024-04-11T07:36:54Z |
| format | Article |
| id | doaj.art-df03968a12ac49bdba26555da1fc8ead |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T07:36:54Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-df03968a12ac49bdba26555da1fc8ead2022-12-22T04:36:43ZengNature PortfolioScientific Reports2045-23222022-11-011211910.1038/s41598-022-23478-1Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney diseaseQiuhong Li0Xian Shao1Saijun Zhou2Zhuang Cui3Hongyan Liu4Tongdan Wang5Xiaoguang Fan6Pei Yu7NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical UniversityDepartment of Epidemiology and Health Statistics, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical UniversityDepartment of Nephrology, Henan Provincial People’s Hospital, Department of Nephrology of Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou UniversityNHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical UniversityAbstract Triglyceride–glucose (TyG) index has been proposed to be a simple, economical, and reliable marker of insulin resistance. We aimed to investigate whether TyG is an independent predictor of hyperuricemia in diabetic kidney disease (DKD) populations by conducting a cross-sectional and longitudinal study. A total of 6,471 patients were enrolled in cross-sectional analysis, and 3,634 patients without hyperuricemia at the baseline were included in longitudinal analysis and were followed up for a median of 23.0 months. Hyperuricemia was categorized as a serum uric acid level ≥ 420 umol/L (7 mg/dL). In this study, 19.58% of participants had hyperuricemia. In the cross-sectional analysis, multivariate logistics regression analysis showed that the ORs (95% CI) for hyperuricemia in the second, third, and fourth TyG quartiles were 1.40 (95% CI 0.73–2.65), 1.69 (95% CI 0.90–3.18), and 4.53 (95% CI 2.39–8.57), respectively, compared with the first quartile. Longitudinally, the Kaplan–Meier survival analysis showed that higher TyG levels predicted higher incidence of hyperuricemia. Multivariate Cox regression model revealed that the hazard ratios for hyperuricemia in the upper quartiles of the TyG index were 1.69 (95% CI 0.97–2.93), 2.23 (95% CI 1.33–3.75), and 2.50 (95% CI 1.46–4.27), respectively, compared with the first quartile. Moreover, the subgroup analyses revealed that the relationship between TyG levels and hyperuricemia was robust in DKD patients. Our findings indicate a significant independent correlation between the TyG index and the risk of hyperuricemia in DKD patients.https://doi.org/10.1038/s41598-022-23478-1 |
| spellingShingle | Qiuhong Li Xian Shao Saijun Zhou Zhuang Cui Hongyan Liu Tongdan Wang Xiaoguang Fan Pei Yu Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease Scientific Reports |
| title | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
| title_full | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
| title_fullStr | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
| title_full_unstemmed | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
| title_short | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
| title_sort | triglyceride glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
| url | https://doi.org/10.1038/s41598-022-23478-1 |
| work_keys_str_mv | AT qiuhongli triglycerideglucoseindexissignificantlyassociatedwiththeriskofhyperuricemiainpatientswithdiabetickidneydisease AT xianshao triglycerideglucoseindexissignificantlyassociatedwiththeriskofhyperuricemiainpatientswithdiabetickidneydisease AT saijunzhou triglycerideglucoseindexissignificantlyassociatedwiththeriskofhyperuricemiainpatientswithdiabetickidneydisease AT zhuangcui triglycerideglucoseindexissignificantlyassociatedwiththeriskofhyperuricemiainpatientswithdiabetickidneydisease AT hongyanliu triglycerideglucoseindexissignificantlyassociatedwiththeriskofhyperuricemiainpatientswithdiabetickidneydisease AT tongdanwang triglycerideglucoseindexissignificantlyassociatedwiththeriskofhyperuricemiainpatientswithdiabetickidneydisease AT xiaoguangfan triglycerideglucoseindexissignificantlyassociatedwiththeriskofhyperuricemiainpatientswithdiabetickidneydisease AT peiyu triglycerideglucoseindexissignificantlyassociatedwiththeriskofhyperuricemiainpatientswithdiabetickidneydisease |