The Importance of Metabolites in Modulating Insulin Sensitivity
BACKGROUND: Metabolism impairment in obese condition usually initially triggered by inflammation and insulin signaling impairment. The involvement of metabolites, including lipids, amino acids, and ketone bodies, in altering insulin sensitivity has been revealed after massive data sets were provided...
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| Format: | Article |
| Language: | English |
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Secretariat of The Indonesian Biomedical Journal
2022-09-01
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| Series: | Indonesian Biomedical Journal |
| Online Access: | https://inabj.org/index.php/ibj/article/view/1872 |
| _version_ | 1811211133475880960 |
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| author | Anna Meiliana Nurrani Mustika Dewi Andi Wijaya |
| author_facet | Anna Meiliana Nurrani Mustika Dewi Andi Wijaya |
| author_sort | Anna Meiliana |
| collection | DOAJ |
| description | BACKGROUND: Metabolism impairment in obese condition usually initially triggered by inflammation and insulin signaling impairment. The involvement of metabolites, including lipids, amino acids, and ketone bodies, in altering insulin sensitivity has been revealed after massive data sets were provided by the studies regarding metabolomics and lipidomics.
CONTENT: Metabolites were now understood to serve more than just the metabolism products, but also as active signaling molecules including in insulin and immunological actions. Different lipid metabolites can serve as signaling molecules to induce insulin resistance of sensitivity through a similar pathway, and impact on the inflammation status. Branched Chain Amino Acids (BCAA) and many amino acids have been correlated with mitochondrial dysfunction and insulin impairment. Ketogenic diet, supplementation and microbiota transplantation become the current strategies to set a preferable metabolites composition to modulate insulin sensitivity.
SUMMARY: Thousands of metabolites can now be measured using technical and bioinformatics developments. Different types of amino acids, fatty acids, and bile acids are being studied in relation to altered metabolic states, particularly obesity and type 2 diabetes mellitus. A thorough knowledge of the metabolic changes that contribute to insulin resistance might lead to the discovery of new targets for enhancing insulin sensitivity and preventing and treating many metabolic disorders.
KEYWORDS: metabolites, insulin resistance, lipids, amino acids, ketone bodies |
| first_indexed | 2024-04-12T05:07:35Z |
| format | Article |
| id | doaj.art-df039f1af6b84aa4aa32f1e1589824d0 |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-04-12T05:07:35Z |
| publishDate | 2022-09-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-df039f1af6b84aa4aa32f1e1589824d02022-12-22T03:46:51ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792022-09-011432264210.18585/inabj.v14i3.1872466The Importance of Metabolites in Modulating Insulin SensitivityAnna Meiliana0Nurrani Mustika Dewi1Andi Wijaya2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363Prodia Education and Research Institute, Jl. Kramat Raya No. 150, Jakarta, 10430Prodia Clinical Laboratory, Jl. Supratman No 43, Bandung 40114BACKGROUND: Metabolism impairment in obese condition usually initially triggered by inflammation and insulin signaling impairment. The involvement of metabolites, including lipids, amino acids, and ketone bodies, in altering insulin sensitivity has been revealed after massive data sets were provided by the studies regarding metabolomics and lipidomics. CONTENT: Metabolites were now understood to serve more than just the metabolism products, but also as active signaling molecules including in insulin and immunological actions. Different lipid metabolites can serve as signaling molecules to induce insulin resistance of sensitivity through a similar pathway, and impact on the inflammation status. Branched Chain Amino Acids (BCAA) and many amino acids have been correlated with mitochondrial dysfunction and insulin impairment. Ketogenic diet, supplementation and microbiota transplantation become the current strategies to set a preferable metabolites composition to modulate insulin sensitivity. SUMMARY: Thousands of metabolites can now be measured using technical and bioinformatics developments. Different types of amino acids, fatty acids, and bile acids are being studied in relation to altered metabolic states, particularly obesity and type 2 diabetes mellitus. A thorough knowledge of the metabolic changes that contribute to insulin resistance might lead to the discovery of new targets for enhancing insulin sensitivity and preventing and treating many metabolic disorders. KEYWORDS: metabolites, insulin resistance, lipids, amino acids, ketone bodieshttps://inabj.org/index.php/ibj/article/view/1872 |
| spellingShingle | Anna Meiliana Nurrani Mustika Dewi Andi Wijaya The Importance of Metabolites in Modulating Insulin Sensitivity Indonesian Biomedical Journal |
| title | The Importance of Metabolites in Modulating Insulin Sensitivity |
| title_full | The Importance of Metabolites in Modulating Insulin Sensitivity |
| title_fullStr | The Importance of Metabolites in Modulating Insulin Sensitivity |
| title_full_unstemmed | The Importance of Metabolites in Modulating Insulin Sensitivity |
| title_short | The Importance of Metabolites in Modulating Insulin Sensitivity |
| title_sort | importance of metabolites in modulating insulin sensitivity |
| url | https://inabj.org/index.php/ibj/article/view/1872 |
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