Association of IL-4 with pachychoroid neovasculopathy
Abstract The purpose of this study was to identify the inflammatory cytokines that were associated with pachychoroid neovasculopathy (PNV). Seventy-five eyes of 75 patients with PNV, 145 eyes of 145 patients with neovascular age-related macular degeneration without pachyvessels, and 150 eyes of 150...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28108-y |
| _version_ | 1797945984647430144 |
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| author | Takashi Baba Ayumi Koyama Ryu Uotani Hitomi Miyake Kodai Inata Shin-ichi Sasaki Yumiko Shimizu Yoshitsugu Inoue Kaori Adachi Eiji Nanba Dai Miyazaki |
| author_facet | Takashi Baba Ayumi Koyama Ryu Uotani Hitomi Miyake Kodai Inata Shin-ichi Sasaki Yumiko Shimizu Yoshitsugu Inoue Kaori Adachi Eiji Nanba Dai Miyazaki |
| author_sort | Takashi Baba |
| collection | DOAJ |
| description | Abstract The purpose of this study was to identify the inflammatory cytokines that were associated with pachychoroid neovasculopathy (PNV). Seventy-five eyes of 75 patients with PNV, 145 eyes of 145 patients with neovascular age-related macular degeneration without pachyvessels, and 150 eyes of 150 normal subjects were examined for the levels of intraocular cytokines. In eyes with PNV, the levels of IL-1α, IL-1β, IL-2, IL-4, IL-10, and VEGF were significantly higher than that of the controls. Logistic regression analysis showed that the highest association with the pachyvessels was found for IL-4, IL-2, and IL-1α. In eyes with PNV, the levels of IL-4, IL-2, IL-5, IL-13, IL-1α, and IL-1β were significantly higher in eyes with both increased choroidal thickness and choroidal vessel diameter. The strongest correlation with the choroidal thickness and vessel diameter was observed for IL-4. In PNV eyes with polypoidal lesions, the levels of IL-4, IL-17, and TNFβ were significantly correlated with the number of polypoidal lesions. Of these cytokines, IL-4 was especially associated with the thickness of the choroidal vessels and the formation of polypoidal lesions. We conclude that IL-4 is most likely involved in establishing the clinical characteristics of PNV and polypoidal vascular remodeling. |
| first_indexed | 2024-04-10T21:03:42Z |
| format | Article |
| id | doaj.art-df03cc2526d04523a8be14a868a1ec34 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T21:03:42Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-df03cc2526d04523a8be14a868a1ec342023-01-22T12:12:16ZengNature PortfolioScientific Reports2045-23222023-01-0113111010.1038/s41598-023-28108-yAssociation of IL-4 with pachychoroid neovasculopathyTakashi Baba0Ayumi Koyama1Ryu Uotani2Hitomi Miyake3Kodai Inata4Shin-ichi Sasaki5Yumiko Shimizu6Yoshitsugu Inoue7Kaori Adachi8Eiji Nanba9Dai Miyazaki10Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori UniversityDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori UniversityDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori UniversityDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori UniversityDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori UniversityDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori UniversityDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori UniversityDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori UniversityResearch Initiative Center, Organization for Research Initiative and Promotion, Tottori UniversityResearch Initiative Center, Organization for Research Initiative and Promotion, Tottori UniversityDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori UniversityAbstract The purpose of this study was to identify the inflammatory cytokines that were associated with pachychoroid neovasculopathy (PNV). Seventy-five eyes of 75 patients with PNV, 145 eyes of 145 patients with neovascular age-related macular degeneration without pachyvessels, and 150 eyes of 150 normal subjects were examined for the levels of intraocular cytokines. In eyes with PNV, the levels of IL-1α, IL-1β, IL-2, IL-4, IL-10, and VEGF were significantly higher than that of the controls. Logistic regression analysis showed that the highest association with the pachyvessels was found for IL-4, IL-2, and IL-1α. In eyes with PNV, the levels of IL-4, IL-2, IL-5, IL-13, IL-1α, and IL-1β were significantly higher in eyes with both increased choroidal thickness and choroidal vessel diameter. The strongest correlation with the choroidal thickness and vessel diameter was observed for IL-4. In PNV eyes with polypoidal lesions, the levels of IL-4, IL-17, and TNFβ were significantly correlated with the number of polypoidal lesions. Of these cytokines, IL-4 was especially associated with the thickness of the choroidal vessels and the formation of polypoidal lesions. We conclude that IL-4 is most likely involved in establishing the clinical characteristics of PNV and polypoidal vascular remodeling.https://doi.org/10.1038/s41598-023-28108-y |
| spellingShingle | Takashi Baba Ayumi Koyama Ryu Uotani Hitomi Miyake Kodai Inata Shin-ichi Sasaki Yumiko Shimizu Yoshitsugu Inoue Kaori Adachi Eiji Nanba Dai Miyazaki Association of IL-4 with pachychoroid neovasculopathy Scientific Reports |
| title | Association of IL-4 with pachychoroid neovasculopathy |
| title_full | Association of IL-4 with pachychoroid neovasculopathy |
| title_fullStr | Association of IL-4 with pachychoroid neovasculopathy |
| title_full_unstemmed | Association of IL-4 with pachychoroid neovasculopathy |
| title_short | Association of IL-4 with pachychoroid neovasculopathy |
| title_sort | association of il 4 with pachychoroid neovasculopathy |
| url | https://doi.org/10.1038/s41598-023-28108-y |
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