Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients
Sampling of the nasal epithelial lining fluid is a potential method to assess exposure to air pollution within the respiratory tract among high risk populations. We investigated associations of short- and long-term particulate matter exposure (PM) and pollution-related metals in the nasal fluid of p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2023-01-01
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| Series: | Environmental Research: Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/2752-5309/acbbe5 |
| _version_ | 1797694628716085248 |
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| author | Hilary L Zetlen Anna Stanley Lee Lina Nurhussien Wendy Sun Choong-Min Kang Antonella Zanobetti Mary B Rice |
| author_facet | Hilary L Zetlen Anna Stanley Lee Lina Nurhussien Wendy Sun Choong-Min Kang Antonella Zanobetti Mary B Rice |
| author_sort | Hilary L Zetlen |
| collection | DOAJ |
| description | Sampling of the nasal epithelial lining fluid is a potential method to assess exposure to air pollution within the respiratory tract among high risk populations. We investigated associations of short- and long-term particulate matter exposure (PM) and pollution-related metals in the nasal fluid of people with chronic obstructive pulmonary disease (COPD). This study included 20 participants with moderate-to-severe COPD from a larger study who measured long-term personal exposure to PM _2.5 using portable air monitors and short-term PM _2.5 and black carbon (BC) using in-home samplers for the seven days preceding nasal fluid collection. Nasal fluid was sampled from both nares by nasosorption, and inductively coupled plasma mass spectrometry was used to determine the concentration of metals with major airborne sources. Correlations of selected elements (Fe, Ba, Ni, Pb, V, Zn, Cu) were determined within the nasal fluid. Associations between personal long-term PM _2.5 and seven day home PM _2.5 and BC exposure and nasal fluid metal concentrations were determined by linear regression. Within nasal fluid samples, concentrations of vanadium and nickel ( r = 0.8) and lead and zinc ( r = 0.7) were correlated. Seven day and long-term PM _2.5 exposure were both associated with higher levels of copper, lead, and vanadium in the nasal fluid. BC exposure was associated with higher levels of nickel in the nasal fluid. Levels of certain metals in the nasal fluid may serve as biomarkers of air pollution exposure in the upper respiratory tract. |
| first_indexed | 2024-03-12T03:00:35Z |
| format | Article |
| id | doaj.art-df04cdc8c99a47ab8ca1c550ddd3d837 |
| institution | Directory Open Access Journal |
| issn | 2752-5309 |
| language | English |
| last_indexed | 2024-03-12T03:00:35Z |
| publishDate | 2023-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Environmental Research: Health |
| spelling | doaj.art-df04cdc8c99a47ab8ca1c550ddd3d8372023-09-03T14:52:56ZengIOP PublishingEnvironmental Research: Health2752-53092023-01-011202100210.1088/2752-5309/acbbe5Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patientsHilary L Zetlen0https://orcid.org/0000-0002-0353-8012Anna Stanley Lee1Lina Nurhussien2Wendy Sun3Choong-Min Kang4Antonella Zanobetti5Mary B Rice6Division of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center , Boston, MA, United States of AmericaDivision of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center , Boston, MA, United States of AmericaDivision of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center , Boston, MA, United States of AmericaDivision of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center , Boston, MA, United States of AmericaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health , Boston, MA, United States of AmericaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health , Boston, MA, United States of AmericaDivision of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center , Boston, MA, United States of AmericaSampling of the nasal epithelial lining fluid is a potential method to assess exposure to air pollution within the respiratory tract among high risk populations. We investigated associations of short- and long-term particulate matter exposure (PM) and pollution-related metals in the nasal fluid of people with chronic obstructive pulmonary disease (COPD). This study included 20 participants with moderate-to-severe COPD from a larger study who measured long-term personal exposure to PM _2.5 using portable air monitors and short-term PM _2.5 and black carbon (BC) using in-home samplers for the seven days preceding nasal fluid collection. Nasal fluid was sampled from both nares by nasosorption, and inductively coupled plasma mass spectrometry was used to determine the concentration of metals with major airborne sources. Correlations of selected elements (Fe, Ba, Ni, Pb, V, Zn, Cu) were determined within the nasal fluid. Associations between personal long-term PM _2.5 and seven day home PM _2.5 and BC exposure and nasal fluid metal concentrations were determined by linear regression. Within nasal fluid samples, concentrations of vanadium and nickel ( r = 0.8) and lead and zinc ( r = 0.7) were correlated. Seven day and long-term PM _2.5 exposure were both associated with higher levels of copper, lead, and vanadium in the nasal fluid. BC exposure was associated with higher levels of nickel in the nasal fluid. Levels of certain metals in the nasal fluid may serve as biomarkers of air pollution exposure in the upper respiratory tract.https://doi.org/10.1088/2752-5309/acbbe5COPDnasal epithelial lining fluidair pollution exposuremetals exposureexposure assessmentPM2.5 |
| spellingShingle | Hilary L Zetlen Anna Stanley Lee Lina Nurhussien Wendy Sun Choong-Min Kang Antonella Zanobetti Mary B Rice Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients Environmental Research: Health COPD nasal epithelial lining fluid air pollution exposure metals exposure exposure assessment PM2.5 |
| title | Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients |
| title_full | Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients |
| title_fullStr | Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients |
| title_full_unstemmed | Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients |
| title_short | Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients |
| title_sort | personal air pollution exposure and metals in the nasal epithelial lining fluid of copd patients |
| topic | COPD nasal epithelial lining fluid air pollution exposure metals exposure exposure assessment PM2.5 |
| url | https://doi.org/10.1088/2752-5309/acbbe5 |
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