Fragile-X Syndrome Is Associated With NMDA Receptor Hypofunction and Reduced Dendritic Complexity in Mature Dentate Granule Cells

Fragile-X Syndrome Is Associated With NMDA Receptor Hypofunction and Reduced Dendritic Complexity in Mature Dentate Granule Cells

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. It is caused by the overexpansion of cytosine-guanine-guanine (CGG) trinucleotide in Fmr1 gene, resulting in complete loss of the fragile X mental retardation protein (FMRP). Previous studies using Fmr1 knockout (...

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Bibliographic Details
Main Authors: Suk-Yu Yau, Luis Bettio, Jason Chiu, Christine Chiu, Brian R. Christie
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
fragile X syndrome (FXS)
NMDA (N-methy-D-aspartate receptor)
dendrite complexity
neurogenesis
dentate gyrus
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00495/full

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