Nogo and Nogo receptor: Relevance to schizophrenia?
The membrane protein Nogo-A and its receptor NgR have been extensively characterized for their role in restricting axonal growth, regeneration, and plasticity in the central nervous system. Recent evidence suggests that Nogo and NgR might constitute candidate genes for schizophrenia susceptibility....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-06-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996113000351 |
| _version_ | 1818869940169474048 |
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| author | Roman Willi Martin E. Schwab |
| author_facet | Roman Willi Martin E. Schwab |
| author_sort | Roman Willi |
| collection | DOAJ |
| description | The membrane protein Nogo-A and its receptor NgR have been extensively characterized for their role in restricting axonal growth, regeneration, and plasticity in the central nervous system. Recent evidence suggests that Nogo and NgR might constitute candidate genes for schizophrenia susceptibility. In this article, we critically review the possibility that dysfunctions related to Nogo-A and NgR might contribute to increased risk for schizophrenia. To this end, we consider the most important insights that have emerged from human genetic and pathological studies and from experimental animal work. Furthermore, we discuss potential mechanisms of Nogo/NgR involvement in neural circuit development and stability, and how mutations or changes in expression levels of these proteins could be developmental risk factors contributing to schizophrenia. |
| first_indexed | 2024-12-19T11:59:06Z |
| format | Article |
| id | doaj.art-df069730af634123904d8884c7a3651e |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-19T11:59:06Z |
| publishDate | 2013-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-df069730af634123904d8884c7a3651e2022-12-21T20:22:33ZengElsevierNeurobiology of Disease1095-953X2013-06-0154150157Nogo and Nogo receptor: Relevance to schizophrenia?Roman Willi0Martin E. Schwab1Brain Research Institute, University of Zurich, Zurich, Switzerland; Department of Health Sciences and Technology, ETH Zurich, Zurich, SwitzerlandCorresponding author at: Brain Research Institute, University of Zurich, and Department of Health Sciences and Technology, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.; Brain Research Institute, University of Zurich, Zurich, Switzerland; Department of Health Sciences and Technology, ETH Zurich, Zurich, SwitzerlandThe membrane protein Nogo-A and its receptor NgR have been extensively characterized for their role in restricting axonal growth, regeneration, and plasticity in the central nervous system. Recent evidence suggests that Nogo and NgR might constitute candidate genes for schizophrenia susceptibility. In this article, we critically review the possibility that dysfunctions related to Nogo-A and NgR might contribute to increased risk for schizophrenia. To this end, we consider the most important insights that have emerged from human genetic and pathological studies and from experimental animal work. Furthermore, we discuss potential mechanisms of Nogo/NgR involvement in neural circuit development and stability, and how mutations or changes in expression levels of these proteins could be developmental risk factors contributing to schizophrenia.http://www.sciencedirect.com/science/article/pii/S0969996113000351SchizophreniaNogo-ANgRRisk factorsAnimal modelsMyelin |
| spellingShingle | Roman Willi Martin E. Schwab Nogo and Nogo receptor: Relevance to schizophrenia? Neurobiology of Disease Schizophrenia Nogo-A NgR Risk factors Animal models Myelin |
| title | Nogo and Nogo receptor: Relevance to schizophrenia? |
| title_full | Nogo and Nogo receptor: Relevance to schizophrenia? |
| title_fullStr | Nogo and Nogo receptor: Relevance to schizophrenia? |
| title_full_unstemmed | Nogo and Nogo receptor: Relevance to schizophrenia? |
| title_short | Nogo and Nogo receptor: Relevance to schizophrenia? |
| title_sort | nogo and nogo receptor relevance to schizophrenia |
| topic | Schizophrenia Nogo-A NgR Risk factors Animal models Myelin |
| url | http://www.sciencedirect.com/science/article/pii/S0969996113000351 |
| work_keys_str_mv | AT romanwilli nogoandnogoreceptorrelevancetoschizophrenia AT martineschwab nogoandnogoreceptorrelevancetoschizophrenia |