Falling Plasmodium knowlesi Malaria Death Rate among Adults despite Rising Incidence, Sabah, Malaysia, 2010–2014
Deaths from Plasmodium knowlesi malaria have been linked to delayed parenteral treatment. In Malaysia, early intravenous artesunate is now recommended for all severe malaria cases. We describe P. knowlesi fatalities in Sabah, Malaysia, during 2012–2014 and report species-specific fatality rates base...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2016-01-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/22/1/15-1305_article |
| _version_ | 1819100348261859328 |
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| author | Giri S. Rajahram Bridget E. Barber Timothy William Matthew J. Grigg Jayaram Menon Tsin W. Yeo Nicholas M. Anstey |
| author_facet | Giri S. Rajahram Bridget E. Barber Timothy William Matthew J. Grigg Jayaram Menon Tsin W. Yeo Nicholas M. Anstey |
| author_sort | Giri S. Rajahram |
| collection | DOAJ |
| description | Deaths from Plasmodium knowlesi malaria have been linked to delayed parenteral treatment. In Malaysia, early intravenous artesunate is now recommended for all severe malaria cases. We describe P. knowlesi fatalities in Sabah, Malaysia, during 2012–2014 and report species-specific fatality rates based on 2010–2014 case notifications. Sixteen malaria-associated deaths (caused by PCR-confirmed P. knowlesi [7], P. falciparum [7], and P. vivax [1] and microscopy-diagnosed “P. malariae” [1]) were reported during 2012–2014. Six patients with severe P. knowlesi malaria received intravenous artesunate at hospital admission. For persons >15 years of age, overall fatality rates during 2010–2014 were 3.4, 4.2, and 1.0 deaths/1,000 P. knowlesi, P. falciparum, and P. vivax notifications, respectively; P. knowlesi–associated fatality rates fell from 9.2 to1.6 deaths/1,000 notifications. No P. knowlesi–associated deaths occurred among children, despite 373 notified cases. Although P. knowlesi malaria incidence is rising, the notification-fatality rate has decreased, likely due to improved use of intravenous artesunate. |
| first_indexed | 2024-12-22T01:01:21Z |
| format | Article |
| id | doaj.art-df07caa05bf34012b7d2720f6dfd4b59 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-22T01:01:21Z |
| publishDate | 2016-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-df07caa05bf34012b7d2720f6dfd4b592022-12-21T18:44:12ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592016-01-01221414810.3201/eid2201.151305Falling Plasmodium knowlesi Malaria Death Rate among Adults despite Rising Incidence, Sabah, Malaysia, 2010–2014Giri S. RajahramBridget E. BarberTimothy WilliamMatthew J. GriggJayaram MenonTsin W. YeoNicholas M. AnsteyDeaths from Plasmodium knowlesi malaria have been linked to delayed parenteral treatment. In Malaysia, early intravenous artesunate is now recommended for all severe malaria cases. We describe P. knowlesi fatalities in Sabah, Malaysia, during 2012–2014 and report species-specific fatality rates based on 2010–2014 case notifications. Sixteen malaria-associated deaths (caused by PCR-confirmed P. knowlesi [7], P. falciparum [7], and P. vivax [1] and microscopy-diagnosed “P. malariae” [1]) were reported during 2012–2014. Six patients with severe P. knowlesi malaria received intravenous artesunate at hospital admission. For persons >15 years of age, overall fatality rates during 2010–2014 were 3.4, 4.2, and 1.0 deaths/1,000 P. knowlesi, P. falciparum, and P. vivax notifications, respectively; P. knowlesi–associated fatality rates fell from 9.2 to1.6 deaths/1,000 notifications. No P. knowlesi–associated deaths occurred among children, despite 373 notified cases. Although P. knowlesi malaria incidence is rising, the notification-fatality rate has decreased, likely due to improved use of intravenous artesunate.https://wwwnc.cdc.gov/eid/article/22/1/15-1305_articlemalariasevere malaria. Plasmodium knowlesiPlasmodium vivaxPlasmodium falciparumdeathsfatal malaria |
| spellingShingle | Giri S. Rajahram Bridget E. Barber Timothy William Matthew J. Grigg Jayaram Menon Tsin W. Yeo Nicholas M. Anstey Falling Plasmodium knowlesi Malaria Death Rate among Adults despite Rising Incidence, Sabah, Malaysia, 2010–2014 Emerging Infectious Diseases malaria severe malaria. Plasmodium knowlesi Plasmodium vivax Plasmodium falciparum deaths fatal malaria |
| title | Falling Plasmodium knowlesi Malaria Death Rate among Adults despite Rising Incidence, Sabah, Malaysia, 2010–2014 |
| title_full | Falling Plasmodium knowlesi Malaria Death Rate among Adults despite Rising Incidence, Sabah, Malaysia, 2010–2014 |
| title_fullStr | Falling Plasmodium knowlesi Malaria Death Rate among Adults despite Rising Incidence, Sabah, Malaysia, 2010–2014 |
| title_full_unstemmed | Falling Plasmodium knowlesi Malaria Death Rate among Adults despite Rising Incidence, Sabah, Malaysia, 2010–2014 |
| title_short | Falling Plasmodium knowlesi Malaria Death Rate among Adults despite Rising Incidence, Sabah, Malaysia, 2010–2014 |
| title_sort | falling plasmodium knowlesi malaria death rate among adults despite rising incidence sabah malaysia 2010 2014 |
| topic | malaria severe malaria. Plasmodium knowlesi Plasmodium vivax Plasmodium falciparum deaths fatal malaria |
| url | https://wwwnc.cdc.gov/eid/article/22/1/15-1305_article |
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