Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation

Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation

Abstract Background Molecular markers for prostate cancer (PCa) are required to improve the early definition of patient outcomes. Atypically large extracellular vesicles (EVs), referred as “Large Oncosomes” (LO), have been identified in highly migratory and invasive PCa cells. We recently developed...

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Bibliographic Details
Main Authors: Chiara Ciardiello, Alessandra Leone, Paola Lanuti, Maria S. Roca, Tania Moccia, Valentina R. Minciacchi, Michele Minopoli, Vincenzo Gigantino, Rossella De Cecio, Massimo Rippa, Lucia Petti, Francesca Capone, Carlo Vitagliano, Maria R. Milone, Biagio Pucci, Rita Lombardi, Federica Iannelli, Elena Di Gennaro, Francesca Bruzzese, Marco Marchisio, Maria V. Carriero, Dolores Di Vizio, Alfredo Budillon
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Extracellular vesicles
Oncosomes
Prostate cancer
Alpha-V integrin
AKT
Online Access:http://link.springer.com/article/10.1186/s13046-019-1317-6

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