A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers
The aim was to assess the gut microbiota of long-livers from Moscow. This study included two groups of patients who signed their consent to participate. The group of long-livers (LL) included 20 participants aged 97–100 years (4 men and 16 women). The second group included 22 participants aged 60–76...
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MDPI AG
2020-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/8/1162 |
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| author | Daria A. Kashtanova Nataliya S. Klimenko Irina D. Strazhesko Elizaveta V. Starikova Oksana E. Glushchenko Denis A. Gudkov Olga N. Tkacheva |
| author_facet | Daria A. Kashtanova Nataliya S. Klimenko Irina D. Strazhesko Elizaveta V. Starikova Oksana E. Glushchenko Denis A. Gudkov Olga N. Tkacheva |
| author_sort | Daria A. Kashtanova |
| collection | DOAJ |
| description | The aim was to assess the gut microbiota of long-livers from Moscow. This study included two groups of patients who signed their consent to participate. The group of long-livers (LL) included 20 participants aged 97–100 years (4 men and 16 women). The second group included 22 participants aged 60–76 years (6 men) without clinical manifestations of chronic diseases (healthy elderly). Gut microbiota was studied by 16S rRNA sequencing. Long-livers underwent a complex geriatric assessment as well as expanded blood biochemistry. Gut microbiota composition in the cohorts was also compared with microbiome in long-livers from Japan and Italy. Russian long-livers’ microbiome contained more beneficial bacteria than healthy elderly including <i>Ruminococcaceae, Christensenellaceae, Lactobacillaceae</i> families. Conditional pathogens like <i>Veillonellaceae, Mogibacteriaceae, Alcaligenaceae, Peptococcaceae, Peptostreptococcaceae</i> were more abundant in the healthy elderly. Compared with Italian and Japanese microbiome LL, the Russian LL appeared to be more similar to the Italian cohort. <i>Bifidobacterium/Coprococcus</i> and <i>Faecalibacterium/Coprococcus</i> balances were associated with femoral and carotid intima–media thickness, respectively. <i>Bifidobacterium/Coriobacteriaceae</i> balance was assessed with the folic acid level and <i>Faecalibacterium/Coriobacteriaceae_u</i> the with Mini Nutritional Assessment score. Long-livers’ microbiome appeared to be unexpectedly balanced. The high representation of beneficial bacteria in long-livers may prevent them from low-grade inflammation and thus protect them from the development of atherosclerosis and other aging-associated conditions. |
| first_indexed | 2024-03-10T18:05:38Z |
| format | Article |
| id | doaj.art-df0c30d9777045d0ab6afb6bf91cdd29 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T18:05:38Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-df0c30d9777045d0ab6afb6bf91cdd292023-11-20T08:32:54ZengMDPI AGMicroorganisms2076-26072020-07-0188116210.3390/microorganisms8081162A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-LiversDaria A. Kashtanova0Nataliya S. Klimenko1Irina D. Strazhesko2Elizaveta V. Starikova3Oksana E. Glushchenko4Denis A. Gudkov5Olga N. Tkacheva6The Stand-Alone Structural Unit of the Pirogov Russian National Research Medical University the “Russian Clinical Research Center for Gerontology” of the Ministry of Healthcare of the Russian Federation, 129226 Moscow, RussiaInstitute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, RussiaThe Stand-Alone Structural Unit of the Pirogov Russian National Research Medical University the “Russian Clinical Research Center for Gerontology” of the Ministry of Healthcare of the Russian Federation, 129226 Moscow, RussiaFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, RussiaFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, RussiaFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, RussiaThe Stand-Alone Structural Unit of the Pirogov Russian National Research Medical University the “Russian Clinical Research Center for Gerontology” of the Ministry of Healthcare of the Russian Federation, 129226 Moscow, RussiaThe aim was to assess the gut microbiota of long-livers from Moscow. This study included two groups of patients who signed their consent to participate. The group of long-livers (LL) included 20 participants aged 97–100 years (4 men and 16 women). The second group included 22 participants aged 60–76 years (6 men) without clinical manifestations of chronic diseases (healthy elderly). Gut microbiota was studied by 16S rRNA sequencing. Long-livers underwent a complex geriatric assessment as well as expanded blood biochemistry. Gut microbiota composition in the cohorts was also compared with microbiome in long-livers from Japan and Italy. Russian long-livers’ microbiome contained more beneficial bacteria than healthy elderly including <i>Ruminococcaceae, Christensenellaceae, Lactobacillaceae</i> families. Conditional pathogens like <i>Veillonellaceae, Mogibacteriaceae, Alcaligenaceae, Peptococcaceae, Peptostreptococcaceae</i> were more abundant in the healthy elderly. Compared with Italian and Japanese microbiome LL, the Russian LL appeared to be more similar to the Italian cohort. <i>Bifidobacterium/Coprococcus</i> and <i>Faecalibacterium/Coprococcus</i> balances were associated with femoral and carotid intima–media thickness, respectively. <i>Bifidobacterium/Coriobacteriaceae</i> balance was assessed with the folic acid level and <i>Faecalibacterium/Coriobacteriaceae_u</i> the with Mini Nutritional Assessment score. Long-livers’ microbiome appeared to be unexpectedly balanced. The high representation of beneficial bacteria in long-livers may prevent them from low-grade inflammation and thus protect them from the development of atherosclerosis and other aging-associated conditions.https://www.mdpi.com/2076-2607/8/8/1162gut microbiotalongevityagingsystemic low-grade inflammationlong-liversbeneficial bacteria |
| spellingShingle | Daria A. Kashtanova Nataliya S. Klimenko Irina D. Strazhesko Elizaveta V. Starikova Oksana E. Glushchenko Denis A. Gudkov Olga N. Tkacheva A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers Microorganisms gut microbiota longevity aging systemic low-grade inflammation long-livers beneficial bacteria |
| title | A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers |
| title_full | A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers |
| title_fullStr | A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers |
| title_full_unstemmed | A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers |
| title_short | A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers |
| title_sort | cross sectional study of the gut microbiota composition in moscow long livers |
| topic | gut microbiota longevity aging systemic low-grade inflammation long-livers beneficial bacteria |
| url | https://www.mdpi.com/2076-2607/8/8/1162 |
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