Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours
Extracellular vesicles are fundamentally significant in the communication between cells. Outer Membrane Vesicles(OMVs) are a special kind of EVs produced by Gram-negative bacteria, which are minute exosome-like particles budding from the outer membrane, which have been found to play essential roles...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1103446/full |
| _version_ | 1797942573728268288 |
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| author | Yang Ge Yang Ge Fengyuan Sun Bo Zhao Fanyang Kong Fanyang Kong Zhaoshen Li Xiangyu Kong Xiangyu Kong Xiangyu Kong |
| author_facet | Yang Ge Yang Ge Fengyuan Sun Bo Zhao Fanyang Kong Fanyang Kong Zhaoshen Li Xiangyu Kong Xiangyu Kong Xiangyu Kong |
| author_sort | Yang Ge |
| collection | DOAJ |
| description | Extracellular vesicles are fundamentally significant in the communication between cells. Outer Membrane Vesicles(OMVs) are a special kind of EVs produced by Gram-negative bacteria, which are minute exosome-like particles budding from the outer membrane, which have been found to play essential roles in diverse bacterial life events, including regulation of microbial interactions, pathogenesis promotion, stress responses and biofilm formation. Recently, and more researches have explored the substantial potentials of EVs as natural functional nanoparticles in the bioengineering applications in infectious diseases, cardiovascular diseases, autoimmune diseases and neurological diseases, such as antibacterial therapy, cancer drugs and immunoadjuvants, with several candidates in clinical trials showing promising efficacy. However, due to the poor understanding of sources, membrane structures and biogenesis mechanisms of EVs, progress in clinical applications still remains timid. In this review, we summarize the latest findings of EVs, especially in gastrointestinal tract tumours, to provide a comprehensive introduction of EVs in tumorigenesis and therapeutics. |
| first_indexed | 2024-04-10T20:10:41Z |
| format | Article |
| id | doaj.art-df0c5eb39e094075953b0635edfb5622 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T20:10:41Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-df0c5eb39e094075953b0635edfb56222023-01-26T13:55:19ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.11034461103446Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumoursYang Ge0Yang Ge1Fengyuan Sun2Bo Zhao3Fanyang Kong4Fanyang Kong5Zhaoshen Li6Xiangyu Kong7Xiangyu Kong8Xiangyu Kong9Changhai Clinical Research Unit, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaDepartment of Gastroenterology, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaChanghai Clinical Research Unit, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaChanghai Clinical Research Unit, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaChanghai Clinical Research Unit, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaDepartment of Gastroenterology, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaChanghai Clinical Research Unit, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaChanghai Clinical Research Unit, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaDepartment of Gastroenterology, Changhai Hospital, Naval Military Medical University, Shanghai, ChinaNational Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, ChinaExtracellular vesicles are fundamentally significant in the communication between cells. Outer Membrane Vesicles(OMVs) are a special kind of EVs produced by Gram-negative bacteria, which are minute exosome-like particles budding from the outer membrane, which have been found to play essential roles in diverse bacterial life events, including regulation of microbial interactions, pathogenesis promotion, stress responses and biofilm formation. Recently, and more researches have explored the substantial potentials of EVs as natural functional nanoparticles in the bioengineering applications in infectious diseases, cardiovascular diseases, autoimmune diseases and neurological diseases, such as antibacterial therapy, cancer drugs and immunoadjuvants, with several candidates in clinical trials showing promising efficacy. However, due to the poor understanding of sources, membrane structures and biogenesis mechanisms of EVs, progress in clinical applications still remains timid. In this review, we summarize the latest findings of EVs, especially in gastrointestinal tract tumours, to provide a comprehensive introduction of EVs in tumorigenesis and therapeutics.https://www.frontiersin.org/articles/10.3389/fonc.2022.1103446/fullextracellular vesicles (EVs)cancerimmunotherapyTLRLPSPAMP |
| spellingShingle | Yang Ge Yang Ge Fengyuan Sun Bo Zhao Fanyang Kong Fanyang Kong Zhaoshen Li Xiangyu Kong Xiangyu Kong Xiangyu Kong Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours Frontiers in Oncology extracellular vesicles (EVs) cancer immunotherapy TLR LPS PAMP |
| title | Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours |
| title_full | Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours |
| title_fullStr | Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours |
| title_full_unstemmed | Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours |
| title_short | Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours |
| title_sort | bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours |
| topic | extracellular vesicles (EVs) cancer immunotherapy TLR LPS PAMP |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1103446/full |
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