Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry
Introduction: Cervical dystonia (CD) is one of the most common forms of adult-onset isolated dystonia. Recently, CD has been classified according to the site of onset and spread, in different clinical subgroups, that may represent different clinical entities or pathophysiologic subtypes. In order to...
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00906/full |
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| author | Francesca Di Biasio Roberta Marchese Giovanni Abbruzzese Ottavia Baldi Marcello Esposito Francesco Silvestre Girolamo Tescione Alfredo Berardelli Alfredo Berardelli Giovanni Fabbrini Giovanni Fabbrini Gina Ferrazzano Roberta Pellicciari Roberto Eleopra Grazia Devigili Francesco Bono Domenico Santangelo Laura Bertolasi Maria Concetta Altavista Vincenzo Moschella Paolo Barone Roberto Erro Alberto Albanese Cesa Scaglione Rocco Liguori Maria Sofia Cotelli Giovanni Cossu Roberto Ceravolo Mario Coletti Moja Maurizio Zibetti Antonio Pisani Martina Petracca Martina Petracca Michele Tinazzi Luca Maderna Paolo Girlanda Luca Magistrelli Luca Magistrelli Salvatore Misceo Marcello Romano Brigida Minafra Nicola Modugno Marco Aguggia Daniela Cassano Giovanni Defazio Laura Avanzino Laura Avanzino |
| author_facet | Francesca Di Biasio Roberta Marchese Giovanni Abbruzzese Ottavia Baldi Marcello Esposito Francesco Silvestre Girolamo Tescione Alfredo Berardelli Alfredo Berardelli Giovanni Fabbrini Giovanni Fabbrini Gina Ferrazzano Roberta Pellicciari Roberto Eleopra Grazia Devigili Francesco Bono Domenico Santangelo Laura Bertolasi Maria Concetta Altavista Vincenzo Moschella Paolo Barone Roberto Erro Alberto Albanese Cesa Scaglione Rocco Liguori Maria Sofia Cotelli Giovanni Cossu Roberto Ceravolo Mario Coletti Moja Maurizio Zibetti Antonio Pisani Martina Petracca Martina Petracca Michele Tinazzi Luca Maderna Paolo Girlanda Luca Magistrelli Luca Magistrelli Salvatore Misceo Marcello Romano Brigida Minafra Nicola Modugno Marco Aguggia Daniela Cassano Giovanni Defazio Laura Avanzino Laura Avanzino |
| author_sort | Francesca Di Biasio |
| collection | DOAJ |
| description | Introduction: Cervical dystonia (CD) is one of the most common forms of adult-onset isolated dystonia. Recently, CD has been classified according to the site of onset and spread, in different clinical subgroups, that may represent different clinical entities or pathophysiologic subtypes. In order to support this hypothesis, in this study we have evaluated whether different subgroups of CD, that clinically differ for site of onset and spread, also imply different sensorimotor features.Methods: Clinical and demographic data from 842 patients with CD from the Italian Dystonia Registry were examined. Motor features (head tremor and tremor elsewhere) and sensory features (sensory trick and neck pain) were investigated. We analyzed possible associations between motor and sensory features in CD subgroups [focal neck onset, no spread (FNO-NS); focal neck onset, segmental spread (FNO-SS); focal onset elsewhere with segmental spread to neck (FOE-SS); segmental neck involvement without spread (SNI)].Results: In FNO-NS, FOE-SS, and SNI subgroups, head tremor was associated with the presence of tremor elsewhere. Sensory trick was associated with pain in patients with FNO-NS and with head tremor in patients with FNO-SS.Conclusion: The frequent association between head tremor and tremor elsewhere may suggest a common pathophysiological mechanism. Two mechanisms may be hypothesized for sensory trick: a gating mechanism attempting to reduce pain and a sensorimotor mechanism attempting to control tremor. |
| first_indexed | 2024-04-12T08:21:26Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T08:21:26Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-df0e0cde2e054ab09e25cfc48bdcfef52022-12-22T03:40:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-08-011110.3389/fneur.2020.00906542167Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia RegistryFrancesca Di Biasio0Roberta Marchese1Giovanni Abbruzzese2Ottavia Baldi3Marcello Esposito4Francesco Silvestre5Girolamo Tescione6Alfredo Berardelli7Alfredo Berardelli8Giovanni Fabbrini9Giovanni Fabbrini10Gina Ferrazzano11Roberta Pellicciari12Roberto Eleopra13Grazia Devigili14Francesco Bono15Domenico Santangelo16Laura Bertolasi17Maria Concetta Altavista18Vincenzo Moschella19Paolo Barone20Roberto Erro21Alberto Albanese22Cesa Scaglione23Rocco Liguori24Maria Sofia Cotelli25Giovanni Cossu26Roberto Ceravolo27Mario Coletti Moja28Maurizio Zibetti29Antonio Pisani30Martina Petracca31Martina Petracca32Michele Tinazzi33Luca Maderna34Paolo Girlanda35Luca Magistrelli36Luca Magistrelli37Salvatore Misceo38Marcello Romano39Brigida Minafra40Nicola Modugno41Marco Aguggia42Daniela Cassano43Giovanni Defazio44Laura Avanzino45Laura Avanzino46IRCCS Policlinico San Martino, Genoa, ItalyIRCCS Policlinico San Martino, Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics and Maternal Child Health, University of Genoa, Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics and Maternal Child Health, University of Genoa, Genoa, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, Italy“Salvatore Maugeri” Foundation, Institute of Telese Terme (BN), Benevento, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyIRCSS Neuromed, Pozzilli, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyIRCSS Neuromed, Pozzilli, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Basic Science, Neuroscience and Sense Organs, Aldo Moro University of Bari, Bari, ItalyFondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, UOC Neurologia 1, Milan, ItalyFondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, UOC Neurologia 1, Milan, ItalyNeurology Unit, Center for Botulinum Toxin Therapy, A.O.U. Mater Domini, Catanzaro, ItalyNeurology Unit, Center for Botulinum Toxin Therapy, A.O.U. Mater Domini, Catanzaro, Italy0Neurologic Unit, University Hospital, Verona, Italy1San Filippo Neri Hospital, ASL Roma 1, Rome, Italy1San Filippo Neri Hospital, ASL Roma 1, Rome, Italy2Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Neuroscience Section, Universitá di Salerno, Baronissi, Italy2Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Neuroscience Section, Universitá di Salerno, Baronissi, Italy3IRCCS Humanitas Research Hospital Humanitas, Milan, Italy4IRCCS Institute of Neurological Sciences, Bologna, Italy4IRCCS Institute of Neurological Sciences, Bologna, Italy5Neurology Unit, ASST Valcamonica, Esine, Italy6Neurology Service and Stroke Unit, Department of Neuroscience, AO Brotzu, Cagliari, Italy7Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy8Neurology Unit, Umberto I Hospital, Turin, Italy9Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy0Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy1Fondazione Policlinico Universitario A. Gemelli – IRCCS, Rome, Italy2Institute of Neurology, Università Cattolica del Sacro Cuore, Rome, Italy3Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy4Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy5Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy6Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy7PhD Program in Clinical and Experimental Medicine and Medical Humanities, University of Insubria, Varese, Italy8Neurologic Unit, San Paolo Hospital, Bari, Italy9Neurology Unit AOOR Villa Sofia Cervello, Palermo, Italy0Parkinson's Disease and Movement Disorders Unit, IRCCS Mondino Foundation, Pavia, ItalyIRCSS Neuromed, Pozzilli, Italy1Neurology Department, Asti Hospital, Asti, Italy2Unit of Neurology, Ospedale Maria Vittoria, Turin, Italy3Neurology Unit, Department of Medical Science and Public Health, University of Cagliari, Cagliari, ItalyIRCCS Policlinico San Martino, Genoa, Italy4Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, ItalyIntroduction: Cervical dystonia (CD) is one of the most common forms of adult-onset isolated dystonia. Recently, CD has been classified according to the site of onset and spread, in different clinical subgroups, that may represent different clinical entities or pathophysiologic subtypes. In order to support this hypothesis, in this study we have evaluated whether different subgroups of CD, that clinically differ for site of onset and spread, also imply different sensorimotor features.Methods: Clinical and demographic data from 842 patients with CD from the Italian Dystonia Registry were examined. Motor features (head tremor and tremor elsewhere) and sensory features (sensory trick and neck pain) were investigated. We analyzed possible associations between motor and sensory features in CD subgroups [focal neck onset, no spread (FNO-NS); focal neck onset, segmental spread (FNO-SS); focal onset elsewhere with segmental spread to neck (FOE-SS); segmental neck involvement without spread (SNI)].Results: In FNO-NS, FOE-SS, and SNI subgroups, head tremor was associated with the presence of tremor elsewhere. Sensory trick was associated with pain in patients with FNO-NS and with head tremor in patients with FNO-SS.Conclusion: The frequent association between head tremor and tremor elsewhere may suggest a common pathophysiological mechanism. Two mechanisms may be hypothesized for sensory trick: a gating mechanism attempting to reduce pain and a sensorimotor mechanism attempting to control tremor.https://www.frontiersin.org/article/10.3389/fneur.2020.00906/fullcervical dystoniatremorsensory trickpainspread |
| spellingShingle | Francesca Di Biasio Roberta Marchese Giovanni Abbruzzese Ottavia Baldi Marcello Esposito Francesco Silvestre Girolamo Tescione Alfredo Berardelli Alfredo Berardelli Giovanni Fabbrini Giovanni Fabbrini Gina Ferrazzano Roberta Pellicciari Roberto Eleopra Grazia Devigili Francesco Bono Domenico Santangelo Laura Bertolasi Maria Concetta Altavista Vincenzo Moschella Paolo Barone Roberto Erro Alberto Albanese Cesa Scaglione Rocco Liguori Maria Sofia Cotelli Giovanni Cossu Roberto Ceravolo Mario Coletti Moja Maurizio Zibetti Antonio Pisani Martina Petracca Martina Petracca Michele Tinazzi Luca Maderna Paolo Girlanda Luca Magistrelli Luca Magistrelli Salvatore Misceo Marcello Romano Brigida Minafra Nicola Modugno Marco Aguggia Daniela Cassano Giovanni Defazio Laura Avanzino Laura Avanzino Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry Frontiers in Neurology cervical dystonia tremor sensory trick pain spread |
| title | Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry |
| title_full | Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry |
| title_fullStr | Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry |
| title_full_unstemmed | Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry |
| title_short | Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry |
| title_sort | motor and sensory features of cervical dystonia subtypes data from the italian dystonia registry |
| topic | cervical dystonia tremor sensory trick pain spread |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00906/full |
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