| Summary: | At present, the great challenge in human genetics is to provide significance to the growing amount of human disease-associated gene variants identified by next generation DNA sequencing technologies. Increasing evidences suggest that model organisms are of pivotal importance to addressing this issue. Due to its genetic tractability, the yeast <i>Saccharomyces cerevisiae</i> represents a valuable model organism for understanding human genetic variability. In the present review, we show how <i>S. cerevisiae</i> has been used to study variants of genes involved in different diseases and in different pathways, highlighting the versatility of this model organism.
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