Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene Variants
At present, the great challenge in human genetics is to provide significance to the growing amount of human disease-associated gene variants identified by next generation DNA sequencing technologies. Increasing evidences suggest that model organisms are of pivotal importance to addressing this issue...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/9/1303 |
| _version_ | 1797519158838034432 |
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| author | Tiziana Cervelli Alvaro Galli |
| author_facet | Tiziana Cervelli Alvaro Galli |
| author_sort | Tiziana Cervelli |
| collection | DOAJ |
| description | At present, the great challenge in human genetics is to provide significance to the growing amount of human disease-associated gene variants identified by next generation DNA sequencing technologies. Increasing evidences suggest that model organisms are of pivotal importance to addressing this issue. Due to its genetic tractability, the yeast <i>Saccharomyces cerevisiae</i> represents a valuable model organism for understanding human genetic variability. In the present review, we show how <i>S. cerevisiae</i> has been used to study variants of genes involved in different diseases and in different pathways, highlighting the versatility of this model organism. |
| first_indexed | 2024-03-10T07:39:07Z |
| format | Article |
| id | doaj.art-df104339d9694ad28a5c2d70a3bf9cfe |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T07:39:07Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-df104339d9694ad28a5c2d70a3bf9cfe2023-11-22T13:12:57ZengMDPI AGGenes2073-44252021-08-01129130310.3390/genes12091303Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene VariantsTiziana Cervelli0Alvaro Galli1Yeast Genetics and Genomics Group, Laboratory of Functional Genetics and Genomics, Institute of Clinical Physiology CNR, Via Moruzzi 1, 56125 Pisa, ItalyYeast Genetics and Genomics Group, Laboratory of Functional Genetics and Genomics, Institute of Clinical Physiology CNR, Via Moruzzi 1, 56125 Pisa, ItalyAt present, the great challenge in human genetics is to provide significance to the growing amount of human disease-associated gene variants identified by next generation DNA sequencing technologies. Increasing evidences suggest that model organisms are of pivotal importance to addressing this issue. Due to its genetic tractability, the yeast <i>Saccharomyces cerevisiae</i> represents a valuable model organism for understanding human genetic variability. In the present review, we show how <i>S. cerevisiae</i> has been used to study variants of genes involved in different diseases and in different pathways, highlighting the versatility of this model organism.https://www.mdpi.com/2073-4425/12/9/1303yeast<i>Saccharomyces cerevisiae</i>functional assaysMendelian diseasecancerhuman gene variants |
| spellingShingle | Tiziana Cervelli Alvaro Galli Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene Variants Genes yeast <i>Saccharomyces cerevisiae</i> functional assays Mendelian disease cancer human gene variants |
| title | Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene Variants |
| title_full | Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene Variants |
| title_fullStr | Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene Variants |
| title_full_unstemmed | Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene Variants |
| title_short | Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene Variants |
| title_sort | yeast as a tool to understand the significance of human disease associated gene variants |
| topic | yeast <i>Saccharomyces cerevisiae</i> functional assays Mendelian disease cancer human gene variants |
| url | https://www.mdpi.com/2073-4425/12/9/1303 |
| work_keys_str_mv | AT tizianacervelli yeastasatooltounderstandthesignificanceofhumandiseaseassociatedgenevariants AT alvarogalli yeastasatooltounderstandthesignificanceofhumandiseaseassociatedgenevariants |