Sepsis-induced acute kidney injury: kidney protection effects by antioxidants
ABSTRACT Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of ab...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Enfermagem
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| Series: | Revista Brasileira de Enfermagem |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000401921&lng=en&tlng=en |
| _version_ | 1818608659456851968 |
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| author | Carolina Ferreira Vasco Mirian Watanabe Cassiane Dezoti da Fonseca Maria de Fátima Fernandes Vattimo |
| author_facet | Carolina Ferreira Vasco Mirian Watanabe Cassiane Dezoti da Fonseca Maria de Fátima Fernandes Vattimo |
| author_sort | Carolina Ferreira Vasco |
| collection | DOAJ |
| description | ABSTRACT Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology. Results: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites. Conclusion: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury. |
| first_indexed | 2024-12-16T14:46:10Z |
| format | Article |
| id | doaj.art-df121301e582444d8dc7fb52058f9920 |
| institution | Directory Open Access Journal |
| issn | 1984-0446 |
| language | English |
| last_indexed | 2024-12-16T14:46:10Z |
| publisher | Associação Brasileira de Enfermagem |
| record_format | Article |
| series | Revista Brasileira de Enfermagem |
| spelling | doaj.art-df121301e582444d8dc7fb52058f99202022-12-21T22:27:47ZengAssociação Brasileira de EnfermagemRevista Brasileira de Enfermagem1984-04467141921192710.1590/0034-7167-2017-0469S0034-71672018000401921Sepsis-induced acute kidney injury: kidney protection effects by antioxidantsCarolina Ferreira VascoMirian WatanabeCassiane Dezoti da FonsecaMaria de Fátima Fernandes VattimoABSTRACT Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology. Results: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites. Conclusion: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000401921&lng=en&tlng=enLesión Renal AgudaSepsisDiosminaHesperidinaEstrés Oxidativo |
| spellingShingle | Carolina Ferreira Vasco Mirian Watanabe Cassiane Dezoti da Fonseca Maria de Fátima Fernandes Vattimo Sepsis-induced acute kidney injury: kidney protection effects by antioxidants Revista Brasileira de Enfermagem Lesión Renal Aguda Sepsis Diosmina Hesperidina Estrés Oxidativo |
| title | Sepsis-induced acute kidney injury: kidney protection effects by antioxidants |
| title_full | Sepsis-induced acute kidney injury: kidney protection effects by antioxidants |
| title_fullStr | Sepsis-induced acute kidney injury: kidney protection effects by antioxidants |
| title_full_unstemmed | Sepsis-induced acute kidney injury: kidney protection effects by antioxidants |
| title_short | Sepsis-induced acute kidney injury: kidney protection effects by antioxidants |
| title_sort | sepsis induced acute kidney injury kidney protection effects by antioxidants |
| topic | Lesión Renal Aguda Sepsis Diosmina Hesperidina Estrés Oxidativo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000401921&lng=en&tlng=en |
| work_keys_str_mv | AT carolinaferreiravasco sepsisinducedacutekidneyinjurykidneyprotectioneffectsbyantioxidants AT mirianwatanabe sepsisinducedacutekidneyinjurykidneyprotectioneffectsbyantioxidants AT cassianedezotidafonseca sepsisinducedacutekidneyinjurykidneyprotectioneffectsbyantioxidants AT mariadefatimafernandesvattimo sepsisinducedacutekidneyinjurykidneyprotectioneffectsbyantioxidants |