ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review
Cecilia Lazea,1 Lucia Sur,1 Mira Florea2 1Department Pediatrics I, Emergency Pediatric Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania; 2Community Medicine Department, University of Medicine and Pharmacy “Iuliu Hatieganu”,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-01-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/rohhad-rapid-onset-obesity-with-hypoventilation-hypothalamic-dysfuncti-peer-reviewed-article-IJGM |
| _version_ | 1818566190251900928 |
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| author | Lazea C Sur L Florea M |
| author_facet | Lazea C Sur L Florea M |
| author_sort | Lazea C |
| collection | DOAJ |
| description | Cecilia Lazea,1 Lucia Sur,1 Mira Florea2 1Department Pediatrics I, Emergency Pediatric Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania; 2Community Medicine Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, RomaniaCorrespondence: Cecilia LazeaDepartment Pediatrics I, Emergency Pediatric Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, 68, Motilor Street, Cluj-Napoca 400370, RomaniaTel +40744353764Fax +40264402539Email cecilialazea@umfcluj.roAbstract: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, autonomic dysregulation (ROHHAD) syndrome is a rare disease with unknown and debated etiology, characterized by precipitous obesity in young children, hypoventilation and autonomic dysregulation with various endocrine abnormalities. Neuroendocrine tumors can be associated in more than half of the cases. This rare condition has a severe outcome because of high morbidity and mortality. We provide a comprehensive description of the etiopathogenetic theories of the disease, clinical presentation, diagnostic workup and treatment possibilities.Keywords: obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation |
| first_indexed | 2024-12-14T01:50:34Z |
| format | Article |
| id | doaj.art-df121a300a53403c879d0aa5b2c3ede6 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-14T01:50:34Z |
| publishDate | 2021-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-df121a300a53403c879d0aa5b2c3ede62022-12-21T23:21:24ZengDove Medical PressInternational Journal of General Medicine1178-70742021-01-01Volume 1431932661612ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A ReviewLazea CSur LFlorea MCecilia Lazea,1 Lucia Sur,1 Mira Florea2 1Department Pediatrics I, Emergency Pediatric Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania; 2Community Medicine Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, RomaniaCorrespondence: Cecilia LazeaDepartment Pediatrics I, Emergency Pediatric Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, 68, Motilor Street, Cluj-Napoca 400370, RomaniaTel +40744353764Fax +40264402539Email cecilialazea@umfcluj.roAbstract: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, autonomic dysregulation (ROHHAD) syndrome is a rare disease with unknown and debated etiology, characterized by precipitous obesity in young children, hypoventilation and autonomic dysregulation with various endocrine abnormalities. Neuroendocrine tumors can be associated in more than half of the cases. This rare condition has a severe outcome because of high morbidity and mortality. We provide a comprehensive description of the etiopathogenetic theories of the disease, clinical presentation, diagnostic workup and treatment possibilities.Keywords: obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulationhttps://www.dovepress.com/rohhad-rapid-onset-obesity-with-hypoventilation-hypothalamic-dysfuncti-peer-reviewed-article-IJGMobesityhypoventilationhypothalamic dysfunctionautonomic dysregulation |
| spellingShingle | Lazea C Sur L Florea M ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review International Journal of General Medicine obesity hypoventilation hypothalamic dysfunction autonomic dysregulation |
| title | ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review |
| title_full | ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review |
| title_fullStr | ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review |
| title_full_unstemmed | ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review |
| title_short | ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review |
| title_sort | rohhad rapid onset obesity with hypoventilation hypothalamic dysfunction autonomic dysregulation syndrome mdash what every pediatrician should know about the etiopathogenesis diagnosis and treatment a review |
| topic | obesity hypoventilation hypothalamic dysfunction autonomic dysregulation |
| url | https://www.dovepress.com/rohhad-rapid-onset-obesity-with-hypoventilation-hypothalamic-dysfuncti-peer-reviewed-article-IJGM |
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