Bilateral hippocampal infarction and amnesia: A case report
The hippocampus along with other structures of the medial temporal lobe plays an important role in the process of learning and memory consolidation. Bilateral hippocampal lesions lead to persistent anterograde amnesia while unilateral damage results in milder, content-specific forms of amne...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500015K.pdf |
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| author | Kostić Smiljana Pasovski Viktor Krsmanović Željko Bošković Željko Kostić Dejan Jovanovski Aleksandar Jović-Stošić Jasmina |
| author_facet | Kostić Smiljana Pasovski Viktor Krsmanović Željko Bošković Željko Kostić Dejan Jovanovski Aleksandar Jović-Stošić Jasmina |
| author_sort | Kostić Smiljana |
| collection | DOAJ |
| description | The hippocampus along with other structures of the medial temporal lobe plays
an important role in the process of learning and memory consolidation.
Bilateral hippocampal lesions lead to persistent anterograde amnesia while
unilateral damage results in milder, content-specific forms of amnesia.
Hippocampus may be affected by an acute or chronic pathologic process from a
wide spectrum of neurological disorders. Case report. A 61-year-old female
patient with a long history of hypertension, glucose intolerance,
hypercholesterolemia and depression was hospitalized for acute anterograde
amnesia, which led to repeated excessive drug taking. By further examinations
that included laboratory tests, electroencephalography, Doppler sonography of
intra- and extracranial vessels and neurovisualization methods [multislice
computed tomography (MSCT) and magnetic resonance imaging (MRI) of the brain]
bilateral hippocampal ischemia that occurred at different times was detected.
Cognitive and neuropsychological evaluation revealed an isolated severe
damage of episodic memory with the inability of retention of new information
which persisted at the control examination three months later. The assumed
mechanism of occurrence of ischemia in this case could be arterio-arterial
embolism. Conclusion. Although ischemic stroke is one of the most common
neurological diseases, ischemic stroke of the hippocampus is rare, the
isolated bilateral presentation with clinical signs of severe amnestic
syndrome in particular. Timely recognition and modern therapeutic approach
could have a favorable impact on the recovery from severe neurological,
cognitive deficit. It could be suggested that in patients with the clinical
image of acute anterograde amnesia and vascular risk factors the MSCT
examination of the brain with computed tomography perfusion and angiography
is performed immediately upon hospitalization. |
| first_indexed | 2024-12-14T12:45:38Z |
| format | Article |
| id | doaj.art-df12bb79ef7f4ecf9590cd34efa529d6 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-14T12:45:38Z |
| publishDate | 2015-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-df12bb79ef7f4ecf9590cd34efa529d62022-12-21T23:00:48ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502015-01-0172654555110.2298/VSP140330015K0042-84501500015KBilateral hippocampal infarction and amnesia: A case reportKostić Smiljana0Pasovski Viktor1Krsmanović Željko2Bošković Željko3Kostić Dejan4Jovanovski Aleksandar5Jović-Stošić Jasmina6Military Medical Academy, Clinic for Neurology, BelgradeMilitary Medical Academy, Clinic for Neurology, BelgradeMilitary Medical Academy, Clinic for Neurology, BelgradeMilitary Medical Academy, Clinic for Neurology, BelgradeMilitary Medical Academy, Institute for Radiology, BelgradeMilitary Medical Academy, Institute for Radiology, BelgradeMilitary Medical Academy, National Poison Control Centre, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeThe hippocampus along with other structures of the medial temporal lobe plays an important role in the process of learning and memory consolidation. Bilateral hippocampal lesions lead to persistent anterograde amnesia while unilateral damage results in milder, content-specific forms of amnesia. Hippocampus may be affected by an acute or chronic pathologic process from a wide spectrum of neurological disorders. Case report. A 61-year-old female patient with a long history of hypertension, glucose intolerance, hypercholesterolemia and depression was hospitalized for acute anterograde amnesia, which led to repeated excessive drug taking. By further examinations that included laboratory tests, electroencephalography, Doppler sonography of intra- and extracranial vessels and neurovisualization methods [multislice computed tomography (MSCT) and magnetic resonance imaging (MRI) of the brain] bilateral hippocampal ischemia that occurred at different times was detected. Cognitive and neuropsychological evaluation revealed an isolated severe damage of episodic memory with the inability of retention of new information which persisted at the control examination three months later. The assumed mechanism of occurrence of ischemia in this case could be arterio-arterial embolism. Conclusion. Although ischemic stroke is one of the most common neurological diseases, ischemic stroke of the hippocampus is rare, the isolated bilateral presentation with clinical signs of severe amnestic syndrome in particular. Timely recognition and modern therapeutic approach could have a favorable impact on the recovery from severe neurological, cognitive deficit. It could be suggested that in patients with the clinical image of acute anterograde amnesia and vascular risk factors the MSCT examination of the brain with computed tomography perfusion and angiography is performed immediately upon hospitalization.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500015K.pdfhippocampusbrain infarctionamnesia, anterogrademagnetic resonance imaging |
| spellingShingle | Kostić Smiljana Pasovski Viktor Krsmanović Željko Bošković Željko Kostić Dejan Jovanovski Aleksandar Jović-Stošić Jasmina Bilateral hippocampal infarction and amnesia: A case report Vojnosanitetski Pregled hippocampus brain infarction amnesia, anterograde magnetic resonance imaging |
| title | Bilateral hippocampal infarction and amnesia: A case report |
| title_full | Bilateral hippocampal infarction and amnesia: A case report |
| title_fullStr | Bilateral hippocampal infarction and amnesia: A case report |
| title_full_unstemmed | Bilateral hippocampal infarction and amnesia: A case report |
| title_short | Bilateral hippocampal infarction and amnesia: A case report |
| title_sort | bilateral hippocampal infarction and amnesia a case report |
| topic | hippocampus brain infarction amnesia, anterograde magnetic resonance imaging |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500015K.pdf |
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