THE INFLUENCE OF CROSS-PLATFORM MICROARRAY DATA INTEGRATION ON GENE EXPRESSION VALUES IN HUMAN BREAST CANCER SAMPLES

Introduction. Currently advances in different fields of biology and medicine accumulated large amount of high-throughput microarray datasets. It allows comparing, merging and analyzing such data in order to get more informative and statistically significant results. However, the process of cross-pla...

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Main Authors: A. O. Frolova, V. S. Bondarenko, M. Yu. Obolenska
Format: Article
Language:English
Published: Ukrmedknyha Publishing House 2016-08-01
Series:Medična Informatika ta Inženerìâ
Online Access:http://ojs.tdmu.edu.ua/index.php/here/article/view/6476
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author A. O. Frolova
V. S. Bondarenko
M. Yu. Obolenska
author_facet A. O. Frolova
V. S. Bondarenko
M. Yu. Obolenska
author_sort A. O. Frolova
collection DOAJ
description Introduction. Currently advances in different fields of biology and medicine accumulated large amount of high-throughput microarray datasets. It allows comparing, merging and analyzing such data in order to get more informative and statistically significant results. However, the process of cross-platform microarray data integration is complicated by different platform designs, that is the kind of probes used, the hybridization paradigm, the labeling and production methods. Such characteristics of microarray platforms should be considered when analyzing datasets from one study and even more when merging datasets.
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spelling doaj.art-df13af6e3ad54e87bf5dec6829c324122023-09-02T22:46:36ZengUkrmedknyha Publishing HouseMedična Informatika ta Inženerìâ1996-19601997-74682016-08-010210.11603/mie.1996-1960.2016.2.64765842THE INFLUENCE OF CROSS-PLATFORM MICROARRAY DATA INTEGRATION ON GENE EXPRESSION VALUES IN HUMAN BREAST CANCER SAMPLESA. O. Frolova0V. S. Bondarenko1M. Yu. Obolenska2Інститут молекулярної біології і генетики НАН УкраїниКиївський національний університет імені Тараса ШевченкаІнститут молекулярної біології і генетики НАН УкраїниIntroduction. Currently advances in different fields of biology and medicine accumulated large amount of high-throughput microarray datasets. It allows comparing, merging and analyzing such data in order to get more informative and statistically significant results. However, the process of cross-platform microarray data integration is complicated by different platform designs, that is the kind of probes used, the hybridization paradigm, the labeling and production methods. Such characteristics of microarray platforms should be considered when analyzing datasets from one study and even more when merging datasets.http://ojs.tdmu.edu.ua/index.php/here/article/view/6476
spellingShingle A. O. Frolova
V. S. Bondarenko
M. Yu. Obolenska
THE INFLUENCE OF CROSS-PLATFORM MICROARRAY DATA INTEGRATION ON GENE EXPRESSION VALUES IN HUMAN BREAST CANCER SAMPLES
Medična Informatika ta Inženerìâ
title THE INFLUENCE OF CROSS-PLATFORM MICROARRAY DATA INTEGRATION ON GENE EXPRESSION VALUES IN HUMAN BREAST CANCER SAMPLES
title_full THE INFLUENCE OF CROSS-PLATFORM MICROARRAY DATA INTEGRATION ON GENE EXPRESSION VALUES IN HUMAN BREAST CANCER SAMPLES
title_fullStr THE INFLUENCE OF CROSS-PLATFORM MICROARRAY DATA INTEGRATION ON GENE EXPRESSION VALUES IN HUMAN BREAST CANCER SAMPLES
title_full_unstemmed THE INFLUENCE OF CROSS-PLATFORM MICROARRAY DATA INTEGRATION ON GENE EXPRESSION VALUES IN HUMAN BREAST CANCER SAMPLES
title_short THE INFLUENCE OF CROSS-PLATFORM MICROARRAY DATA INTEGRATION ON GENE EXPRESSION VALUES IN HUMAN BREAST CANCER SAMPLES
title_sort influence of cross platform microarray data integration on gene expression values in human breast cancer samples
url http://ojs.tdmu.edu.ua/index.php/here/article/view/6476
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