Salvianolic Acid B Inhibits Ferroptosis and Apoptosis during Myocardial Ischemia/Reperfusion Injury via Decreasing the Ubiquitin-Proteasome Degradation of GPX4 and the ROS-JNK/MAPK Pathways

Salvianolic Acid B Inhibits Ferroptosis and Apoptosis during Myocardial Ischemia/Reperfusion Injury via Decreasing the Ubiquitin-Proteasome Degradation of GPX4 and the ROS-JNK/MAPK Pathways

Myocardial ischemia/reperfusion injury (MIRI) is related to ferroptosis and apoptosis elicited by reactive oxygen species (ROS). In this research, we investigated the protective effect of salvianolic acid B (SAB) as a natural antioxidant on ferroptosis and apoptosis in the MIRI process, and discusse...

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Bibliographic Details
Main Authors: Xiaojin Xu, Chenhan Mao, Chengbo Zhang, Meng Zhang, Jianbin Gong, Xindong Wang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
salvianolic acid B
myocardial ischemia/reperfusion injury (MIRI)
ferroptosis
apoptosis
reactive oxygen species (ROS)
GPX4
Online Access:https://www.mdpi.com/1420-3049/28/10/4117

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