A study on the preparation conditions of lidocaine microemulsion based on multi-objective genetic algorithm

A study on the preparation conditions of lidocaine microemulsion based on multi-objective genetic algorithm

Background: Topical lidocaine microemulsion preparations with low toxicity, low irritation, strong transdermal capability and convenient administration are urgently needed.Methods: Box-Behnken design was performed for three preparation conditions of 5% lidocaine microemulsions: mass ratio of the mas...

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Bibliographic Details
Main Authors:	Yuchao Qiao, Xuchun Wang, Hao Ren, Yu Cui, Jiahui Ren, Chongqi Hao, Zhiyang Zhao, Jing Liu, Ruiqing Zhao, Yiting Li, Qingping Tian, Lixia Qiu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-09-01
Series:	Frontiers in Pharmacology
Subjects:	lidocaine microemulsion multi-objective optimization genetic algorithm Pareto non-inferior solution non-dominated sorting genetic algorithm-II
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1272454/full

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